A versatile theranostic nanodevice based on an orthogonal bioconjugation strategy for efficient targeted treatment and monitoring of triple negative breast cancer

Publication date: Available online 30 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): María Victoria Cano-Cortés, Saúl Abenhamar Navarro-Marchal, María Paz Ruiz-Blas, Juan José Díaz-Mochón, Juan Antonio Marchal, Rosario M. Sánchez-MartínAbstractA novel chemical-based orthogonal bioconjugation strategy to produce tri-functionalised nanoparticles (NPs) carrying doxorubicin (DOX), near-infrared cyanine dye (Cy7) and a homing peptide CRGDK, a peptide specifically binds to neuropilin-1 (Nrp-1) overexpressed on triple negative breast cancer (TNBC) cells, has been validated. These theranostic NPs have been evaluated in vitro and in vivo using an orthotopic xenotransplant mouse model using TNBC cells. In vitro assays show that theranostic NPs improve the therapeutic index in comparison with free DOX. Remarkably, in vivo studies showed preferred location of theranostic NPs in the tumor area reducing the volume at the same level than free DOX while presenting lower side effects. This multifunctionalized theranostic nanodevice based on orthogonal conjugation strategies could be a good candidate for the treatment and monitoring of Nrp-1 overexpressing tumors. Moreover, this versatile nanodevice can be easily adapted to treat and monitor different cancer types by adapting the conjugation strategy.Graphical AbstractAn effective, safe and versatile nanodevice for in vivo theranostic to target tumor vasculature has been successfully developed. Herein...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research