H-Ras activation and fibroblast-induced TGF- β signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma.

In conclusion, we demonstrate the presence of laminin-332 in the invasive front of cSCC tumors and report a new Ras/TGF-β-dependent mechanism that promotes laminin-332 accumulation and cancer cell invasion. PMID: 31655292 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31655292?dopt=Abstract

Source: Matrix Biology - October 23, 2019 Category: Molecular Biology Authors: Siljamäki E, Rappu P, Riihilä P, Nissinen L, Kähäri VM, Heino J Tags: Matrix Biol Source Type: research