Differential development of large-cell neuroendocrine or small-cell lung carcinoma upon inactivation of 4 tumor suppressor genes [Medical Sciences]

High-grade neuroendocrine lung malignancies (large-cell neuroendocrine cell carcinoma, LCNEC, and small-cell lung carcinoma, SCLC) are among the most deadly lung cancer conditions with no optimal clinical management. The biological relationships between SCLC and LCNEC are still largely unknown and a current matter of debate as growing molecular data reveal high...

Source: Proceedings of the National Academy of Sciences - October 28, 2019 Category: Science Authors: Sara Lazaro, Miriam Perez–Crespo, Corina Lorz, Aleȷandra Bernardini, Marta Oteo, Ana Belen Enguita, Eduardo Romero, Pilar Hernandez, Laura Tomas, Miguel Angel Morcillo, Jesus M. Paramio, Mirentxu Santos Tags: Biological Sciences Source Type: research