Bone marrow-derived mesenchymal stem cells repair severe acute pancreatitis by secreting miR-181a-5p to target PTEN/Akt/TGF- β1 signaling.

CONCLUSION: BMSCs alleviate SAP and reduce inflammatory responses and apoptosis by secreting miR-181a-5p to target PTEN/Akt/TGF-β1 signaling. Hence, BMSCs-miR-181a-5p could serve as potential therapeutic target for SAP. PMID: 31654716 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31654716?dopt=Abstract

Source: Cellular Signalling - October 21, 2019 Category: Cytology Authors: Li HY, He HC, Song JF, Du YF, Guan M, Wu CY Tags: Cell Signal Source Type: research