Redd1 protects against post ‑infarction cardiac dysfunction by targeting apoptosis and autophagy.

In conclusion, this study demonstrated that Redd1 overexpression protects against the development and persistence of heart failure post MI by reducing apoptosis and enhancing autophagy via the mTOR signaling pathway. The present study clearly demonstrated that Redd1 is a therapeutic target in the development of heart failure after MI.
PMID: 31638187 [PubMed - as supplied by publisher]

Source: International Journal of Molecular Medicine - October 3, 2019 Category: Molecular Biology Authors: Huang P, Fu J, Chen L, Ju C, Wu K, Liu H, Liu Y, Qi B, Qi B, Liu L Tags: Int J Mol Med Source Type: research