Commentary: The gift of life —With a price

For patients with end-stage organ disease, transplantation is often the best —and sometimes the only—therapy to provide symptomatic and prognostic benefit. For patients with renal or cardiac disease, dialysis and mechanical circulatory support are one option, but little else exists for patients with severe liver or lung function deficit. Survival after single, solid orga n transplant is excellent, with 5-year graft survivals for kidney, liver, heart, and lung quoted as 75%, 75%, 79%, and 56%, respectively, according to the 2017 reports from the Scientific Registry of Transplant Recipients.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research

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Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The week of April 23-27 has been designated as National Pediatric Transplant Week.  This week is to bring attention to the great need for organ donations and to honor  donors and their families whose incredibly selfless gift has given someone the gift of life.While most of us will never experience the need for a transplant, there are many of us who know someone who has a debilitating condition such as kidney dialysis that are in need of a transplant.Right now there are almost 2,000 children on the national transplant list.  Those needing hearts, lungs, eyes, tissue, liver, kidney, or some other body part are...
Source: Pediatric Health Associates - Category: Pediatrics Tags: Volunteer Opportunities Source Type: news
In conclusion, most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflammaging. Together, immunosenescence and inflammaging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of gerontologists have chall...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: Peritoneal dialysis appears to be an effective replacement therapy for patients with a previous history of solid-organ transplantation. PMID: 29162679 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, we found that IS status was associated with a significant increase in Hannum DNA methylation, likely as a consequence of the accumulation of cardiovascular risk factors, and near signification with Horvath method. Patients with IS were biologically older than controls, a difference that was more obvious in young stroke. This could open up the possibility of useful new biomarker of stroke risk. Latest Headlines from Fight Aging! A Profile of Kelsey Moody and Ichor Therapeutics https://www.fightaging.org/archives/2016/09/a-profile-of-kelsey-moody
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
An organ transplant is a life-changing event extending far beyond the operating room, the clinics and the hospital walls. Read about five children, one young adult and their families, whose lives were forever changed by the Pediatric Transplant Center at Boston Children’s Hospital. Lydia’s liver transplant, a mom’s gift Dawn Cavanagh gave her daughter life twice — first when she was born and, again, when she gave 13-year-old Lydia a piece of her liver last summer. The donor-approval process, which occurs with Boston Children’s partner Lahey Hospital &Medical Center, required hours of...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories double lung transplant ECMO heart failure heart transplant Heart transplant program heart-lung transplant Heung Bae Kim Intestine and Multivisceral Transplant Program Khashayar Vakili kidney transplant Kidney Source Type: news
There’s something you should know about chronic kidney disease. Most doctors will tell you there is no alternative treatments for kidney problems besides costly dialysis or a transplant to deal with impaired renal function. What Is Kidney Failure? Kidney dialysis is a treatment that uses a special machine to filter harmful wastes, salt and excess from your blood. But there is another option. It’s called stem cell biotherapy, and it offers new hope to those with this life-threatening disease. You may think your kidneys are just fine and you have nothing to worry about. But consider this… What Causes Kidn...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health Source Type: news
French Intensive Care Society, International congress - Réanimation 2016. Ann Intensive Care. 2016 Jun;6(Suppl 1):50 Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubin C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas ...
Source: Australian Family Physician - Category: Primary Care Authors: Tags: Ann Intensive Care Source Type: research
Organ transplantation saves lives. Once considered a last resort for critically ill patients, it is now a practical treatment for freeing kidney patients from dialysis machines and giving patients dying from heart, liver, lung and pancreatic disease a second chance for life. Unfortunately, the number of human organs available for transplantation has never been sufficient to meet the need. Many transplant candidates die waiting for an organ that does not come. The 2006 revision of the Uniform Anatomical Gift Act (UAGA) was an attempt to legislatively find a way to alleviate this shortage.
Source: Value in Health - Category: Global & Universal Authors: Source Type: research
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