Prenatal Omega-3 And Omega-6 Polyunsaturated Fatty Acids And Childhood Atopic Dermatitis
ConclusionIn this racially diverse cohort, higher 2nd trimester n-6 PUFAs were associated with atopic dermatitis in children of women with atopy. PUFAs may represent a modifiable risk factor for atopic dermatitis, particularly in individuals with a familial predisposition.
CONCLUSIONS: Short-term changes in exposure and subsequently in the spectrum of major contact allergens can best be illustrated by clinical surveillance based on routinely collected data and, if needed, preventive measures can be initiated. In addition to time trend analyses, subgroup analyses may offer important clues regarding the identification of sensitizing and eliciting exposures, respectively. PMID: 31728552 [PubMed - as supplied by publisher]
The objective of this study was to test the hypothesis that comorbid type 2 immune diseases confer protection against morbidity and mortality due to acute infection. Design: Retrospective cohort study of patients hospitalized with an acute infection between November 2008 and January 2016 using electronic health record data. Setting: Single tertiary-care academic medical center. Patients: Admissions to the hospital through the emergency department with likely infection at the time of admission who may or may not have had a type 2 immune-mediated disease, defined as asthma, allergic rhinitis, atopic dermatitis, or f...
Publication date: Available online 13 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Dr. Ivan D. Cardona, Dr. Erin E. Kempe, Dr. Christine Lary, Ms. Julia H. Ginder, Dr. Neal JainAbstractBackgroundStudies evaluating bathing frequency in pediatric atopic dermatitis (AD) are limited. Parents of children with AD often receive conflicting information, leading to frustration and confusion.ObjectiveTo evaluate efficacy of twice-daily, soaking baths, followed by immediate application of an occlusive moisturizer (i.e. soak-and-seal [SS]), versus twice-weekly SS baths, in the acute manage...
We present a case of unilateral dermatitis of the chest developing in a patient with a history of allergy to metal. A name tag attached magnetically to his work uniform was identified as the cause of the eruption. Unilateral eruption of the chest can be a manifestation of allergic contact dermatitis to metal objects in breast pockets or attached to clothing.
Capsule summary: Protein coding variants in DOK2, CD200R1 and genes of the IL13 pathway contribute to disease risk in atopic dermatitis and have the potential to target treatment decisions in atopic dermatitis.
Recent years have seen an increase in the number of cases of allergic contact dermatitis from (meth)acrylates in nail products, precipitating new European recommendations for patch testing.The British Journal of Dermatology
This article reviews the role of ILC in allergic skin diseases with a major focus on ILC2. While group 2 ILC are suggested to contribute to the pathogenesis of type 2 dominated inflammation as seen in atopic dermatitis, we have shown that lack of ILC2 in type 1 dominated contact hypersensitivity results in enhanced inflammation, suggesting a regulatory role of ILC2 in this context. We provide a concept of how ILC2 may influence context dependent the mutual counterbalance between type I and type II immune responses in allergic skin diseases.
Atopic dermatitis (AD) may impact health related quality of life (HRQOL) from a combination of signs, symptoms and comorbid anxiety, depression, and other atopic disease1, 2. Quality adjusted life years (QALYs) is a measure of health status and used in cost-effectiveness research. QALYs are estimated using health utility weights, where zero is the worst possible state of health and one is equivalent to perfect health. However, few studies examined the impact of AD on health utility scores.