Effect of Olive leaves extract on the antidiabetic effect of glyburide for possible herb-drug interaction

Publication date: Available online 11 October 2019Source: Saudi Pharmaceutical JournalAuthor(s): Maged S. Abdel-Kader, Gamal A. Soliman, Rehab F. Abdel-Rahman, Abdulaziz S. Saeedan, Reham M. Abd-Elsalam, Hanan A. OgalyAbstractThe concomitant use of olive leaves (OL) and glyburide (GLB) is a possible therapy for diabetic patients. However, there is no report about the effect of OL on the antidiabetic effect of GLB till now. In the current study, the possible interaction of olive leaves extract (OLE) with GLB was assessed to determine if there was any pharmacological benefit over GLB alone. Seven groups of male Sprague Dawley rats were used. Normal rats of the 1st group treated with 2 mL/kg of 3% Tween 80 (vehicle). The 2nd-5th groups were diabetic rats received vehicle, GLB (5 mg/kg), OLE low dose and OLE high dose respectively, while the 6th-7th groups administered combinations of GLB plus OLE low dose and GLB plus OLE high dose, respectively. All treatments were administered orally once daily for 8 weeks.The use of GLB+OLE-500 obviously improved fasting blood glucose (FBG), insulin and glycated hemoglobin (HbA1c) in diabetic rats (95.5±5.55 mg/dL, 6.8±0.16 mg/dL and 6.1±0.29%, respectively) compared to those treated with GLB monotherapy (140.0±6.36 mg/dL, 5.4±0.19 mg/dL and 7.0±0.20%, respectively). The lipid profile [triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)] was significant...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research