Quantification of Multiple Bacteria in Calcified Structural Valvular Heart Disease

Genome studies of heart valve tissue (HVT) in patients with structural valvular heart disease (sVHD) and acute infective endocarditis (aIE) showed polymicrobial infections. Subject of this study is the quantification of bacterial DNA in HVT of sVHD in comparison to aIE. It will be examined whether the bacterial DNA concentration can be used as surrogate marker to differentiate chronic and acute infections. DNA was isolated from HVT of 100 patients with sVHD and 23 microbiologically positively tested patients with aIE.

Source: Seminars in Thoracic and Cardiovascular Surgery - October 8, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Andreas Oberbach, Nadine Schlichting, Maik Friedrich, Stefanie Lehmann, Yvonne Kullnick, Maximilian Pichlmaier, Christian Hagl, Erik Bagaev, the CardiOmics group, the Clinical Microbiology group, the Clinical Management group Tags: ADULT – Original Submission Source Type: research