Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro.
CONCLUSION: We comprehensively evaluated the effect of 22 novel CYP2D6 variants on the metabolism of clonidine for the first time and hoped corresponding data provide a reference for metabolism of clonidine for further studies in vivo, and extend our understanding of the clinical drug toxicity or ineffectiveness by CYP2D6 genetic polymorphism.
PMID: 31585114 [PubMed - as supplied by publisher]
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Li XY, Hu XX, Yang F, Yuan LJ, Cai JP, Hu GX Tags: Chem Biol Interact Source Type: research
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