Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in knee osteoarthritis: a controlled, double-blind clinical trial

AbstractPurposeTo compare the clinical and laboratory outcomes of intra-articular injections of culture-expanded bone-derived mesenchymal stem cells (MSCs) with or without platelet-rich plasma (PRP) to intra-articular corticosteroid injections for the treatment of knee osteoarthritis (OA).MethodsForty-seven patients with radiographic and symptomatic knee OA were randomized into three groups for intra-articular injections: autologous bone marrow-derived culture-expanded MSCs (n = 16); autologous bone marrow-derived culture-expanded MSCs + PRP (n = 14); and corticosteroid (n = 17). The outcomes were assessed by the Knee Injury and Osteoarthritis Outcome Score (KOOS) and range of motion (ROM) at baseline, 1, 2, 3, 6, 9 and 12 months and intra-articular cytokines analysis at baseline, 6 and 12 months postoperatively.ResultsThe three groups showed significant improvement in most KOOS domains and global score at 1st month and all domains and global score at 12-month follow-up (p 
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research

Related Links:

ConclusionsTolerability of opioids is low and efficacy is not clinically relevant in controlled studies from 4 to 24  weeks for osteoarthritis pain.SignificanceWithin the context of randomized controlled trials (4 –24 weeks), opioids provided no clinically relevant pain relief and no clinically relevant reduction in disability compared with placebo in chronic osteoarthritis pain (hip, knee). Number needed to treat for an additional dropout due to side effects was 5 (95% confidence interval 4–7). Two stud ies found no signals of abuse and addiction. The frequency of serious adverse events including dea...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: REVIEW ARTICLE Source Type: research
Authors: Sackner MA, Lopez JR, Banderas V, Adams JA Abstract This review deals with opioid addiction, chronic pain, and an innovative, noninvasive technology with simultaneous, beneficial applications for both conditions. This technology, called passive simulated jogging device (GENTLE JOGGER, JD) targets addiction and pain by increasing endothelial nitric oxide (NO) bioavailability. It can be self-administered while sitting or lying without resorting to multitasking thereby allowing watching television or operating a computer while effortless, physical activity is produced from motorized foot pedals repetitively s...
Source: Journal of Opioid Management - Category: Addiction Tags: J Opioid Manag Source Type: research
All medications come with a dose of risk. From minor side effects to life-threatening allergic reactions, every decision to take a medication should be made only after the expected benefits are weighed against the known risks. You aren’t on your own in this: your doctor, your pharmacist, and a trove of information are available for your review. Recently, I wrote about how newly approved drugs often accumulate new warnings about their safety, including a gout medication that garnered a new warning due to an increased risk of death. Now, according to a new study, the common prescription pain medication tramadol ma...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Pain Management Source Type: blogs
Myoscience, a medtech company based in California, has developed the iovera° cryoanalgesia device. The device was FDA cleared in 2013, with an additional clearance in 2017 for knee pain, and uses cryotherapy to freeze peripheral nerves to reduce ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Orthopedic Surgery Pain Management Source Type: blogs
Before the height of the opioid crisis, research had well-established older Blacks ’ reluctance to use opioids due to concerns about side effects, addiction, and overdose. Our study found that 30% of Blacks used opioid medications within the past 30 days to manage joint pain. Given this proportion of users, we investigated demographic, social, clinical, and behavioral patterns d istinguishing opioid consumers and non-consumers. Descriptive statistics, chi-square, one-way ANOVA, and qualitative content analysis summarize data for community-dwelling Black adults (≥50 years age) with symptomatic osteoarthritis.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
Authors: Lee B, Sodhi N, Anis HK, Ehiorobo JO, Mont MA Abstract INTRODUCTION: There has been a rapid increase in opioid-related morbidity and mortality worldwide, and the dangers of excessive opioid use have been observed in patients with chronic musculoskeletal pain, including those diagnosed with knee osteoarthritis. Pain management is an important component of nonoperative treatment in knee osteoarthritis and frequently entails the use of opioids. However, this management technique is not without risks, such as addiction, morbidity, and mortality. Therefore, the purpose of this study was to review the existing l...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
Funding Opportunity RFA-NS-18-043 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and validation of novel therapeutic targets to facilitate the development of pain therapeutics. Specifically, the focus of this FOA is on the basic science discovery of targets in the peripheral nervous system, central nervous system, immune system or other tissues in the body that can be used to develop treatments that have minimal side effects and little to no abuse/addiction liability. Research supported by this FOA must include rigorous validation studies...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
(Reuters)—An experimental osteoarthritis drug developed by Pfizer Inc and Eli Lilly and Co achieved its main goal of lowering pain in a late stage trial, the companies said on Wednesday, potentially offering a safer alternative to opioids. Opioid abuse has reached epidemic proportions in the United States and drugmakers have been looking for less addictive... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Drug Updates Osteoarthritis Eli Lilly and Co experimental osteoarthritis drug Opioid abuse opioid epidemic Pfizer Inc. safer alternative to opioids tanezumab Source Type: research
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 30 June 2018Source: Pharmacological ResearchAuthor(s): Jabeen Haleem DarakhshanAbstractChronic pain conditions such as low back pain and osteoarthritis are the most prominent causes of disability worldwide. Morphine and other opioid drugs are the gold standard treatment for severe pain, including surgical pain, but the use of these drugs for chronic pain is limited largely because long term use of these drugs is associated with drug abuse and hyperalgesia which produces a negative impact on the treatment. Non-addictive treatments for chronic pain are, therefore, highly needed. Commonly us...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
More News: Addiction | Arthroscopy | Clinical Trials | Corticosteroid Therapy | Laboratory Medicine | Orthopaedics | Osteoarthritis | Pain | Radiography | Sports Medicine | Stem Cell Therapy | Stem Cells