Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells
Patients with T-cell immunodeficiencies are generally treated with allogeneic hematopoietic stem cell transplantation, but alternatives are needed for patients without matched donors. An innovative intrathymic gene therapy approach that directly targets the thymus might improve outcomes.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Marie Pouzolles, Alice Machado, Micka ël Guilbaud, Magali Irla, Sarah Gailhac, Pierre Barennes, Daniela Cesana, Andrea Calabria, Fabrizio Benedicenti, Arnauld Sergé, Indu Raman, Quan-Zhen Li, Eugenio Montini, David Klatzmann, Oumeya Adjali, Naomi Taylor Source Type: research
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