The impact of steroids on the injured podocytes in nephrotic syndrome

Publication date: Available online 3 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Seyed Mahdi Hosseiniyan Khatibi, Mohammadreza Ardalan, Sima Abediazar, Sepideh Zununi VahedAbstractNephrotic syndrome (NS), a common chronic kidney disease, embraces a variety of kidney disorders. Though Glucocorticoids (GCs) are generally used in the treatment of NS, their mechanism of action is poorly understood. A plethora of evidence indicates that podocytes are considered as the main target cells for the therapeutic strategies to prevent NS. GCs regulate the transactivation and transrepression of genes in podocytes that affect their morphological and cytoskeletal features, motility, apoptosis, and survival rate. Moreover, they prevent protein leakage through the glomerular barrier membrane by affecting the synthesis, trafficking, and posttranslational modifications of slit diaphragms components, podocytes’ intercellular junctions. The response to the treatment is variable among different ethnics and populations and resistance to the steroids is detected in almost 50% of adult patients. Not only do pharmacokinetics and pharmacogenetics of steroids play a role in GC resistance but also the genetic variations in one or more podocyte related genes are connected with the steroid resistance in cases with NS. The focus of this review is to explain the underlying cellular and molecular mechanisms of GCs in podocytes. Understanding the mechanisms by which...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research