Functional significance of MAIT cells in psoriatic arthritis.
CONCLUSION: MAIT cells are poly functional; produce multiple cytokines (IL-17A, IFN-γ, TNF-α). Here, we demonstrated synovial fluid MAIT cells as a major source of IL-17A and majority of MAIT cells were CD8+. Functionally active IL-23R on these migrated MAIT cells brings a new dimension. They may not need MR1 associated activation rather lesional IL-23 in the synovium can independently regulate these critical Tc17 CD8+ MAIT cells. Thus, these cells likely to be a part of the IL-23/IL-17A cytokine network and play a critical role in the pathogenesis of PsA.
PMID: 31541902 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Raychaudhuri SK, Abria C, Mitra A, Raychaudhuri SP Tags: Cytokine Source Type: research
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