Modelling the electrical activity of skeletal muscle tissue using a multi-domain approach.

Modelling the electrical activity of skeletal muscle tissue using a multi-domain approach. Biomech Model Mechanobiol. 2019 Sep 16;: Authors: Klotz T, Gizzi L, Yavuz UŞ, Röhrle O Abstract Electromyography (EMG) can be used to study the behaviour of the motor neurons and thus provides insights into the physiology of the central nervous system. However, due to the high complexity of neuromuscular control, EMG signals are challenging to interpret. While the exact knowledge of the excitation patterns of a specific muscle within an in vivo experimental setting remains elusive, simulations allow to systematically investigate EMG signals in a controlled environment. Within this context, simulations can provide virtual EMG data, which, for example, can be used to validate and optimise signal analysis methods that aim to estimate the relationship between EMG signals and the output of motor neuron pools. However, since existing methods, which are employed to compute EMG signals, exhibit deficiencies with respect to the physical model itself as well as with respect to numerical aspects, we propose a novel homogenised continuum model that closely resolves the electro-physiological behaviour of skeletal muscle tissue. The proposed model is based on an extension of the well-established bidomain model and includes a biophysically detailed description of the electrical activity within the tissue, which is due to the depolarisation of the muscle fib...
Source: Biomechanics and Modeling in Mechanobiology - Category: Biomedical Science Authors: Tags: Biomech Model Mechanobiol Source Type: research