Dietary capsaicin-mediated attenuation of hypertension in a rat model of renovascular hypertension.
Conclusion: Dietary capsaicin may alleviate 2K1C renovascular hypertension, probably via enhancing phosphorylation of Akt and eNOS. Abbreviations: 2K1C: 2-kidney, 1-clip hypertension model; Akt: protein kinase B; Ang II: angiotensin II; ANOVA: measures analysis of variance; BP: blood pressure; EC: endothelial cell; eNOS: endothelial nitric oxide synthase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; L-NAME, LN: Nω-Nitro-L-arginine methyl ester hydrochloride; MA: mesenteric arteries; MAP: mean arterial blood pressure; NO: nitric oxide; PKA: protein kinase A; PVDF: polyvinylidene difluoride; SBP: Systolic blood pressure; SHR: spontaneously hypertensive rats; SN: sympathetic nervous; TRPV1: transient receptor potential vanilloid type 1; WKY: Wistar Kyoto rats.
PMID: 31518162 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Hypertension - Category: Cardiology Authors: Segawa Y, Hashimoto H, Maruyama S, Shintani M, Ohno H, Nakai Y, Osera T, Kurihara N Tags: Clin Exp Hypertens Source Type: research
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