Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients with Heart Failure and Reduced Ejection Fraction:PARADIGM-HF.

We examined the association of the number of signs of congestion (jugular venous distention, edema, rales, and S3) with the primary outcome (cardiovascular death or HF hospitalization), its individual components, and all-cause mortality using time-updated, multivariable-adjusted Cox regression. We further evaluated whether sacubitril/valsartan reduced congestion during follow-up, and whether improvement in congestion is related to changes in clinical outcomes and QoL, assessed by Kansas City Cardiomyopathy Questionnaire clinical summary scores (KCCQ-OSS). Results: Among 8380 participants, 0, 1, 2, and 3+ signs of congestion were present in 70%, 21%, 7%, and 2%. Patients with baseline congestion were older, more often female, had higher Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) risk scores and lower KCCQ-OSS (p
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research

Related Links:

Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Chronological aging as well as biological aging accelerated by various pathologies such as diabetes and obesity contribute to cardiovascular aging, and structural and functional tissue damage of the heart and vasculature. Cardiovascular aging in humans is characterized by structural pathologic remodeling including cardiac and vascular fibrosis, hypertrophy, stiffness, micro- and macro-circulatory impairment, left ventricular diastolic dysfunction precipitating heart failure with either reduced or preserved ejection fraction, and cardiovascular cell death. Cellular senescence, an important hallmark of aging, is a critical f...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
European Journal of Heart Failure, Accepted Article.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Viewpoint Source Type: research
AbstractBackgroundContemporary survival trends of Dilated Cardiomyopathy (DCM) patients are largely unknown. The aims of this study are to describe clinical descriptors, survival trends and the prognostic impact of etiological characterization in DCM patients.MethodsDCM patients were consecutively enrolled and divided into 4 groups according to the period of enrolment: 1st: 1978 ‐1984; 2nd: 1985 ‐1994; 3rd: 1995 ‐2004; 4th: 2005 ‐2015. A cohort of patients with DCM with specific etiology, enrolled from 2005 to 2015, was also analyzed.ResultsOver a mean follow ‐up of 12±8 years, 1284 DCM patients (52...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
HIF-1α and CD73 expression in cardiac leukocytes correlates with the severity of myocarditis in end-stage Chagas disease patients. J Leukoc Biol. 2020 May 25;: Authors: Eberhardt N, Sanmarco LM, Bergero G, Favaloro RR, Vigliano C, Aoki MP Abstract Chronic Chagas cardiomyopathy is the main infectious myocarditis worldwide. Almost 30% of Trypanosoma cruzi infected individuals develop slow and progressive myocarditis that leads to ventricular dilation and heart failure. Heart transplantation is an established, valuable therapeutic option for end-stage Chagas disease patients. Although the pathophys...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Tags: J Leukoc Biol Source Type: research
This article aims to review the key connections in the epidemiology and etiopathophysiology of type 2 diabetes and heart failure
Source: Clinics in Geriatric Medicine - Category: Geriatrics Authors: Source Type: research
Abstract Diabetes mellitus predisposes affected individuals to a significant spectrum of cardiovascular complications, one of the most debilitating in terms of prognosis is heart failure. Indeed, the increasing global prevalence of diabetes mellitus and an aging population has given rise to an epidemic of diabetes mellitus-induced heart failure. Despite the significant research attention this phenomenon, termed diabetic cardiomyopathy, has received over several decades, understanding of the full spectrum of potential contributing mechanisms, and their relative contribution to this heart failure phenotype in the sp...
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
AbstractMyocarditis is a multifactorial disorder, characterized by an inflammatory reaction in the myocardium, predominantly triggered by infectious agents, but also by antigen mimicry or autoimmunity in susceptible individuals. Unless spontaneously resolved, a chronic inflammatory course concludes with cardiac muscle dysfunction portrayed by ventricular dilatation, clinically termed inflammatory cardiomyopathy (Infl-CM). Treatment strategies aim to resolve chronic inflammation and preserve cardiac function. Beside standard heart failure treatments, which only play a supportive role in this condition, systemic immunosuppre...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
ConclusionsThe conformational auto ‐epitope targeted by cardio‐pathogenic β1‐receptor autoantibodies is faithfully conserved in cyclopeptide homologues of the β1ECII loop bearing the NDPK211 –214 motif and the C209↔C215 bridge while lacking cysteine C216. Such molecules provide promising tools for novel diagnostic and therapeutic approaches in β1‐autoantibody‐positive CHF.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
More News: Cardiology | Cardiomyopathy | Cardiovascular | Clinical Trials | Diovan | Enalapril | Heart | Heart Failure | Study