Prognostic Implications of Congestion on Physical Examination Among Contemporary Patients with Heart Failure and Reduced Ejection Fraction:PARADIGM-HF.

Conclusions: In HFrEF, the physical exam continues to provide significant, independent prognostic value even beyond symptoms, NPs, and MAGGIC risk score. Sacubitril/valsartan improved congestion to a greater extent than enalapril. Reducing congestion in the outpatient setting is independently associated with improved QoL and reduced cardiovascular events, including mortality. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT01035255. PMID: 31510768 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31510768?dopt=Abstract

Source: Circulation - September 11, 2019 Category: Cardiology Authors: Selvaraj S, Claggett B, Pozzi A, McMurray JJV, Jhund PS, Packer M, Desai AS, Lewis EF, Vaduganathan M, Lefkowitz MP, Rouleau JL, Shi VC, Zile MR, Swedberg K, Solomon SD Tags: Circulation Source Type: research