Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2 –HMOX1 axis

In this study, we first screened a library of 386 natural products and found that xanthohumol (Xn), a prenylated flavonoid found in hops, displayed high anti-PRRSV activity by inhibiting PRRSV adsorption onto and internalization into cells. Transcriptome sequencing revealed that Xn treatment stimulates genes associated with the antioxidant response in the nuclear factor-erythroid 2-related factor 2 (Nrf2) signalling pathway. Xn causes increased expression of Nrf2, HMOX1, GCLC, GCLM, and NQO1 in Marc-145 cells. The action of Xn against PRRSV proliferation depends on Nrf2 in Marc-145 cells and porcine alveolar macrophages (PAMs). This finding suggests that Xn significantly inhibits PRRSV proliferation and decreases viral-induced oxidative stress by activating the Nrf2 –HMOX1 pathway. This information should be helpful for developing a novel prophylactic and therapeutic strategy against PRRSV infection.
Source: Veterinary Research - Category: Veterinary Research Source Type: research

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AbstractIn Xayaboury province, located in the northern region of Lao PDR, the foot and mouth disease (FMD) vaccination campaign just began in 2009. Up until now, a small number of farms have been vaccinated. When FMD outbreaks occur, it is interesting to determine the risk factors of FMD, especially in the area where vaccination rates are low. The questionnaire survey, using a case-control design at the household level, was carried out. From 59 villages with a total number of 434 households, 181 households who experienced FMD were assigned as case households, 146 households without FMD occurrence inside the outbreak villag...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
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Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
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Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
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Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
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Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research
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Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
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Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
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Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
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