Neuroimaging of suicidal thoughts and behaviors in bipolar disorder: ideas and considerations for future research - van Velzen LS.

Suicide is common in Bipolar Disorder (BD). The estimated prevalence is 20-30 times higher in BD patients than in the general population and almost half of the individuals with BD attempt suicide during their lives 1. An increasing number of stu...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Commentary Source Type: news

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We examined the concentrations of chemokines and related substances in the brain tissue from these two groups using the Bio-Plex Pro™ Human Chemokine Panel 40-Plex. We performed multiple regression analysis with covariates. The levels of CCL1, CCL8, CCL13, CCL15, CCL17, CCL19, CCL20, CXCL11, and IL-10 were significantly decreased, whereas the IL-16 levels were significantly increased in the suicide completers after adjustment with the Benjamini-Hochberg method to control for type Ⅰ errors (Q 
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Are you always in control and always perfectly put together? Are you professionally successful, a great friend, and always showing a happy face to the world?  But what about on the inside? Is there something in the background or in the past that you don’t talk about?  Do you feel disconnected, like no one knows the “real” you? Deep down do you just know something is wrong? Well, you might have “perfectly hidden depression.” Today Gabe speaks with Dr. Margaret Rutherford who has done extensive work on the relationship between perfectionism and depression.  Dr. Rutherford tells u...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Depression General Happiness Interview LifeHelper Mental Health and Wellness Perfectionism Personality Podcast Psychiatry Psychology Research Self-Esteem Self-Help The Psych Central Show Trauma Source Type: blogs
Deep brain stimulation (DBS) of a region called the subcallosal cingulate appears to be safe and effective at reducing symptoms of depression in patients with treatment-resistant depression over time, according to asmall study inAJP in Advance.Previous studies suggest that up to one-third of all patients with major depression have treatment-resistant depression (that is, they fail to experience symptom improvements during two or more antidepressant trials). “Given that patients with treatment-resistant depression are highly susceptible to recurrent depressive episodes, the ability of DBS or any treatment to support l...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance Andrea Crowell bipolar disorder DBS deep brain stimulation functioning HAM-D subcallosal cingulate surgery treatment-resistant depression Source Type: research
Are you so happy that you can’t understand depression? Not us! While Gabe and Jackie can’t relate to that level of positivity, there are lots of people in the world who simply can’t fathom what depression feels like. Despite their best efforts, naturally happy people can have a hard time understanding depression and in Episode 2, we discuss how to explain depression to happy people, including both of our spouses who are, to be honest, annoyingly peppy. We give tips on how to approach the topic and share our own personal experiences of having this hard-to-understand conversation. SUBSCRIBE &REVIEW ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Depression Family Not Crazy Podcast Source Type: blogs
CONCLUSIONS: In>8 years of observation, most participants experienced a robust and sustained antidepressant response to SCC DBS. PMID: 31581800 [PubMed - as supplied by publisher]
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
On today’s show, Gabe talks with Dr. Jessi Gold, a self-described misinformation crusader.  In addition to being a practicing psychiatrist, Dr. Gold’s career has focused on writing about mental health and mental illness for a lay audience. Join us as Gabe and Dr. Jessi talk about common sources of psychiatric misinformation, the perils of the supplement industry, how mental health and mental illness are often portrayed incorrectly in the popular media, and why she decided to pursue a very specific type of writing career. SUBSCRIBE &REVIEW Guest information for ‘Dr. Jessi’ Podcast Episode...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Health-related Interview Mental Health and Wellness Podcast Psychiatry Psychology The Psych Central Show Women's Issues Source Type: blogs
It is crucial to appropriately treat pediatric bipolar disorder to improve quality of life and to reduce future risks, including the risk of suicides. Mood stabilizers and antipsychotic drugs remain major treatment strategies. The manic or hypomanic switch in patients who are initially suspected to have unipolar depression and are treated with SSRI is a known phenomenon. Although antidepressants, including SSRIs as a standalone medication, have no evidence for bipolar disorder treatment, it is important to recognize what is known about the combination use of an SSRI with a mood stabilizer or an antipsychotic drug.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research
Bipolar disorder (BD) has the highest suicide risk among mental health disorders, and earlier illness onset increases the risk of attempting suicide. Although several studies have examined suicide attempts (SA), nonsuicidal self-injury (NSSI), and suicidal ideation (SI) among youth with BD, the literature remains sparse with regard to correlates and putative predictors. Therefore, we examined the lifetime prevalence and correlates of SA, NSSI, and SI in a relatively large sample group of adolescents with BD.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research
Longitudinal neuroimaging during adolescence/young adulthood, when bipolar disorder (BD) commonly emerges, can help elucidate the neurodevelopmental pathophysiology of BD. Adults with BD have shown reduced structural integrity in the uncinate fasciculus (UF), a white matter (WM) tract providing major connections between the amygdala and  ventral prefrontal cortex (vPFC), important in emotion regulation. In this longitudinal diffusion tensor imaging (DTI) study of adolescents/young adults, we hypothesized differences in age- and time-related changes in UF integrity in BD compared with healthy control (HC) subjects.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: 2018 Klingenstein Third Generation Foundation Award for Research In Depression or Suicide, Supported by the Klingenstein Third Generation Foundation Source Type: research
 In the first full episode of Not Crazy, we learn a little more about the new co-host, Jackie, and her history with chronic illness and depression. Gabe rants about person-first language and how nitpicking verbiage is distracting from more pressing matters in the lives of those living with mental illness.  Overall, we decide that “crazy” is not a dirty word and there are other, more time-sensitive, things we should be focusing on that can benefit the mental health community.  SUBSCRIBE &REVIEW About The Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Not Crazy Podcast Self-Help Stigma Source Type: blogs
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