Electrocortical high frequency activity and respiratory entrainment in 6-hydroxydopamine model of Parkinson's disease.

Electrocortical high frequency activity and respiratory entrainment in 6-hydroxydopamine model of Parkinson's disease. Brain Res. 2019 Sep 06;:146439 Authors: Cavelli M, Prunell G, Costa G, Velásquez N, Gonzalez J, Castro-Zaballa S, Lima MMS, Torterolo P Abstract Parkinson's disease is characterized by motor symptoms (akinesia, rigidity, etc.), which are associated with the degeneration of the dopaminergic neurons of the midbrain. In addition, olfactory impairment that usually develops before the detection of motor deficits, is detected in 90% of Parkinsonian patients. Recent studies in mammals, have shown that slow cortical potentials phase-lock with nasal respiration. In several cortical areas, gamma synchronization of the electrographic activity is also coupled to respiration, suggesting than nasal respiratory entrainment could have a role in the processing of olfactory information. In the present study, we evaluate the role of midbrain dopaminergic neurons, in the modulation of the electrocorticogram activity and its respiratory entrainment during wakefulness and sleep. For this purpose, we performed a unilateral lesion of dopaminergic neurons of the substantia nigra pars compacta of the rat, with 6-hydroxydopamine. An increase in beta (20-35 Hz) together with a decrease in gamma power (60-95 Hz) in the motor cortex ipsilateral to the lesion was observed during wakefulness. These results correlated with the degree of motor alter...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research