Molecular characterization and diagnostic criteria of renal cell carcinoma with emphasis on liquid biopsies.

Molecular characterization and diagnostic criteria of renal cell carcinoma with emphasis on liquid biopsies. Expert Rev Mol Diagn. 2019 Sep 09;: Authors: Cimadamore A, Massari F, Santoni M, Mollica V, Di Nunno V, Cheng L, Lopez-Beltran A, Scarpelli M, Montironi R, Moch H Abstract Introduction: The current WHO classification of renal cell carcinoma (RCC) is based on the 2013 International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Over the past 6 years, important genomic and transcriptomic studies performed on RCC reported a comprehensive molecular description of RCC pathogenic alterations. Such molecular findings pave the way for an integrated classification, based on histopathology aspects and molecular alterations in order to personalize the clinical management of RCC. Areas covered: The aim of this review is to evaluate the current knowledge and the potential value of liquid biopsy in renal cell cancer. Studies on presence and analysis of circulating tumor DNA (ctDNA), circulating RNA, specific microRNA, long non-coding RNA, and circulating tumor cells are reported for each phase of disease, from the diagnostic setting to the localized disease and, lastly, in the metastatic stage. Expert opinion: Advantages of liquid biopsies compared to serial tissue sampling are numerous. However, some limitations must be addressed before considering liquid biopsy as a non-invasive biomarker of clinical u...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research