Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice

Cardiovascular diseases are the main cause of mortality in obesity. Despite advanced understanding, the mechanisms that regulate cardiac progenitor cells (CPC) survival in pathological conditions are not clear. Low IGF-1 plasma levels are correlated to obesity, cardiomyopathy and CPC death, so this work aimed to investigate IGF-1 therapeutic potential on cardiomyopathy and its relationship with the survival, proliferation and differentiation of CPC in Western diet-induced obesity.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - September 8, 2019 Category: Nutrition Authors: Daniela Andrade, Genilza Oliveira, Luciana Menezes, Ana L úcia Nascimento, Simone Carvalho, Ana Carolina Stumbo, Alessandra Thole, Érica Garcia-Souza, Anibal Moura, Laís Carvalho, Erika Cortez Source Type: research