Splenic serum from portal hypertensive patients enhances liver stem cell proliferation and self-renewal via the IGF-II/ERK signaling pathway

Hypersplenism is a serious complication of portal hypertension (PH) and can affect the prognosis of liver disease. Liver stem cells (LSCs) are involved in liver regeneration and hepatocarcinogenesis after liver cirrhosis.

Source: Digestive and Liver Disease - September 4, 2019 Category: Gastroenterology Authors: Jiangwei Li, Ren Li, Wei Jiang, Jin Sun, Jun Li, Ying Guo, Kai Zhu, Chen Zhang, Guangyao Kong, Zongfang Li Tags: Liver, Pancreas and Biliary Tract Source Type: research