RGD-functionalized magnetosomes are efficient tumor radioenhancers for X-rays and protons

Publication date: Available online 24 August 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Maha Hafsi, Sandra Preveral, Christopher Hoog, Joel Hérault, Géraldine Adryanczyk Perrier, Christopher T Lefèvre, Hervé Michel, David Pignol, Jérôme Doyen, Thierry Pourcher, Olivier Humbert, Juliette Thariat, Béatrice CambienAbstractAlthough chemically synthesized ferro/ferrimagnetic nanoparticles have attracted great attention in cancer theranostics, they lack radio-enhancement efficacy due to low targeting and internalization ability. Herein, we investigated the potential of RGD-tagged magnetosomes, bacterial biogenic magnetic nanoparticles naturally coated with a biological membrane and genetically engineered to express an RGD peptide, as tumor radioenhancers for conventional radiotherapy and protontherapy. Although native and RGD-magnetosomes similarly enhanced radiation-induced damage to plasmid DNA, RGD-magnetoprobes were able to boost the efficacy of radiotherapy to a much larger extent than native magnetosomes both on cancer cells and in tumors. Combined to magnetosomes@RGD, protontherapy exceeded the efficacy of X-rays at equivalent doses. Also, increased secondary emissions were measured after irradiation of magnetosomes with protons versus photons. Our results indicate the therapeutic advantage of using functionalized magnetoparticles to sensitize tumors to both X-rays and protons and strengthens the c...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research

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ConclusionsMultiscale approach ’s predictive capabilities are based on the fundamental scientific knowledge. Their strength is in relation to actual physical, chemical, and biological processes that take place following the ions incidence on tissue. This makes the approach flexible and versatile to include various conditions, s uch as the degree of aeration or the presence of sensitizing nanoparticles, related to particular cases. The ideas for how the MSA can contribute to an improved optimization of therapy planning are summarized in the review.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research
Authors: Streffer C Abstract Hanns Langendorff (1902-1974) was an eminent radiobiologist and a visionary, who not only helped found the field, but also made significant scientific contributions. He was a member of the first editorial board of IJRB and actually published a paper in its first issue about the radio-protector 5-hydroxytryptamine. Langendorff started working in the field of radiobiology in 1929 and became director of the "Radiologisches Institut" of Freiburg University in 1936. His studies impressively show the development of radiobiology over decades in areas such as radiation-induced cell de...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
About half of all Americans are cremated when they die. So when a 69-year-old man was cremated in Arizona in 2017, it didn’t seem out of the ordinary — until doctors learned that his body may have put others at risk of radiation exposure. In 2017, the man was admitted to a hospital for low blood pressure treatment, according to a new research letter published in JAMA. But unbeknownst to his doctors, the man had been treated at the Mayo Clinic Arizona just the day before, where he had been injected with lutetium 177, a radiopharmaceutical used to combat his pancreatic cancer. When the man died two days after bei...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime medicine Source Type: news
Odontology pp 1 –8 |Cite asOriginal ArticleFirst Online:21 January 2019AbstractBreast cancer has developed to become the leading type of cancer in females. For this study, 80 women were examined after chemotherapy for breast cancer and compared to 80 healthy age-matched women. This cross-sectional study comprised a dental examination with number of teeth, caries frequency (DMFT) and the presence of periodontal diseases (PSI). With the help of X-rays (OPG), the number of root canal fillings and apical lesions (LEO/LPO) were recorded. Furthermore, the education level, body mass index (BMI), smoking habits and general h...
Source: Dental Technology Blog - Category: Dentistry Source Type: news
In this study, we compared the long-term side effects of proton radiation to equivalent doses of X-rays in the initiation and progression of premalignant lesions in a lung cancer susceptible mouse model (K-rasLA1). We show proton irradiation causes more complex DNA damage that is not completely repaired resulting in increased oxidative stress in the lungs both acutely and persistently. We further observed K-rasLA1 mice irradiated with protons had an increased number and size of initiated and premalignant lesions and adenomas that were often infiltrated with inflammatory cells. Proton irradiated mice had a lower median surv...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
Conclusions: The addition of vascular-targeted AuNPs significantly improved the treatment effect of liposomal doxorubicin after RT, consistent with the increased liposome accumulation observed in tumors in the imaging study. Using this approach with a liposomal drug delivery system can increase specific tumor delivery of chemotherapeutics, which has the potential to significantly improve tumor response and reduce the side effects of both RT and chemotherapy.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusions: The initial results showed the integrated system’s potential for imaging and monitoring X-PDT XL and XF emissions during NP irradiation. The initial results also show that NPs’ the dose-effectiveness of XL and XF emission depend on incident X-ray energy. Future work will examine these correlations for the LiGa5O8:Cr and KI NPs using the imaging platform.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: New System Designs and Emerging Technologies Source Type: research
ConclusionsThe experimental results demonstrate that GNP-mediated chemoradiation has the potential to improve cancer care in the near future through enhancement of the local radiation dose and controlled delivery of anticancer drugs.
Source: Cancer Nanotechnology - Category: Cancer & Oncology Source Type: research
Publication date: January 2018 Source:Journal of Photochemistry and Photobiology B: Biology, Volume 178 Author(s): Anke König, Nadja Zöller, Stefan Kippenberger, August Bernd, Roland Kaufmann, Paul G. Layer, Anja Heselich Ionizing and near-infrared radiation are both part of the therapeutic spectrum in cancer treatment. During cancer therapy ionizing radiation is typically used for non-invasive reduction of malignant tissue, while near-infrared photobiomodulation is utilized in palliative medical approaches, e.g. for pain reduction or impairment of wound healing. Furthermore, near-infrared is part of the solar w...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
ConclusionIntra-oral administration of rebamipide liquid prevented oral mucositis dose-dependently accompanied by the suppression of inflammatory expression in the radiation-induced rats ’ glossitis model.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
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