RGD-functionalized magnetosomes are efficient tumor radioenhancers for X-rays and protons

Publication date: Available online 24 August 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Maha Hafsi, Sandra Preveral, Christopher Hoog, Joel Hérault, Géraldine Adryanczyk Perrier, Christopher T Lefèvre, Hervé Michel, David Pignol, Jérôme Doyen, Thierry Pourcher, Olivier Humbert, Juliette Thariat, Béatrice CambienAbstractAlthough chemically synthesized ferro/ferrimagnetic nanoparticles have attracted great attention in cancer theranostics, they lack radio-enhancement efficacy due to low targeting and internalization ability. Herein, we investigated the potential of RGD-tagged magnetosomes, bacterial biogenic magnetic nanoparticles naturally coated with a biological membrane and genetically engineered to express an RGD peptide, as tumor radioenhancers for conventional radiotherapy and protontherapy. Although native and RGD-magnetosomes similarly enhanced radiation-induced damage to plasmid DNA, RGD-magnetoprobes were able to boost the efficacy of radiotherapy to a much larger extent than native magnetosomes both on cancer cells and in tumors. Combined to magnetosomes@RGD, protontherapy exceeded the efficacy of X-rays at equivalent doses. Also, increased secondary emissions were measured after irradiation of magnetosomes with protons versus photons. Our results indicate the therapeutic advantage of using functionalized magnetoparticles to sensitize tumors to both X-rays and protons and strengthens the case for developing biogenic magnetopartic...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research