Advanced MRI analysis to detect white matter brain injury in growth restricted newborn lambs

ConclusionsThe neuropathology associated with FGR in neonatal preterm lambs is subtle and imaging detection may require advanced MRI and tract-based analysis techniques. Fixel-based analysis of 3-tissue CSD demonstrates that the preterm neonatal FGR brain shows evidence of macrostructural (cross-sectional) deficits in white matter subsequent to altered antenatal development. These findings can inform analysis of similar brain pathology in neonatal infants.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research