Stress Cardiomyopathy (Takotsubo syndrome) Following Accidental Methadone Poisoning; Report of Two Pediatric Cases.
Stress Cardiomyopathy (Takotsubo syndrome) Following Accidental Methadone Poisoning; Report of Two Pediatric Cases. Arch Acad Emerg Med. 2019;7(1):e22 Authors: Dehghani K, Shojaie M, Pourdavood AH, Khajouei M Abstract Methadone poisoning has become more common in the pediatric population due to extensive use of methadone maintenance therapy (MMT). It is associated with decreased level of consciousness, coma, respiratory distress and cardiac intoxication. The cardiac complications have been reported to be QT prolongation, torsade de pointes, coronary artery disease, arrhythmia, stress cardiomyopathy and death. We herein report two pediatric patients with accidental methadone poisoning who developed stress cardiomyopathy and cardiac failure. The first case was a 4-yaer-old girl and the second one was an 18-month-old girl both being accidentally poisoned with methadone syrup and were brought with decreased level of consciousness. Both were diagnosed to suffer from congestive heart failure based on echocardiography. However, the first case passed away despite appropriate treatment, while the second one survived the condition and was discharged with good condition and was symptom free at 6-month follow-up. PMID: 31432032 [PubMed]
Abstract The ability of the selenium nanoparticles (SeNPs) to capture mercury (Hg) is a subject of interest as this concept can be applied to reduce mercury poisoning cases to certain extent. In this work, SeNPs were fabricated on a paper and used as sorbent for capturing mercury vapor. The formation of the stable HgSe on the paper sorbent after the sequestration was visible to the naked eye for mercury concentration of higher than 200 μg L-1, corresponding with the discoloration of the paper sorbent from dark orange to gray color. The gray color was more intense with increasing Hg concentrations from 200 t...
Condition: Ischemic Heart Disease Intervention: Device: cardio pulmonary bypass machine Sponsor: Assiut University Not yet recruiting
A prospective phase I/II trial of noninvasive cardiac radioablation in high risk patients with treatment-refractory episodes of ventricular arrhythmias demonstrated acceptable primary endpoint 90-day and 6-month safety profile with 11% serious adverse event (SAE) rate, 94% reduction in ventricular tachycardia (VT) episodes, and 89% 6-month overall survival (OS). Longer-term safety and efficacy of this technique is reported.
No abstract available
On the heels of the DAPA-HF outcomes trial, DEFINE-HF shows adding the SGLT-2 inhibitor to standard meds improved other endpoints heart failure patients care about, whether or not they had diabetes.Medscape Medical News
Conclusion: The present study exhibited favorable antagonistic effects of S. cerevisiae S3, as a probiotic yeast, on MSSA and MRSA strains. Based on the findings of this study, the compounds produced by this yeast can be used to control S. aureus infections; however, further similar studies should be conducted to confirm the findings of the present study. PMID: 31523409 [PubMed]
Publication date: Available online 17 September 2019Source: The Annals of Thoracic SurgeryAuthor(s): Valentino Bianco, Arman Kilic, Thomas G. Gleason, Edgar Aranda-Michel, Yisi Wang, Forozan Navid, Ibrahim SultanAbstractBackgroundAn increase in the life expectancy of the general population has led to heightened numbers of elderly patients in need of coronary artery bypass grafting (CABG). Surgical revascularization in octogenarians is becoming more commonplace and outcomes in this cohort continue to gain relevance.MethodsAll patients who underwent isolated CABG (n=7048) at the University of Pittsburgh Medical Center from 2...
This study compares the outcome of post-lobectomy patients in relation to the analgesic method used: parenteral analgesia (PA) vs. PVB + PA, and provides justification for the routine use of PVB in all patients where CEA is contraindicated. METHODS: We randomized 213 consecutive patients undergoing open lobectomy to benefit from two different protocols of postoperative analgesia: PA vs. PVB +PA. We compared the frequency of cardiac hemodynamic, respiratory, pleural or surgical-related complications. RESULTS: After lobectomy, the PVB patients (72/213) were found to have a significantly lower frequency of congestive ...
Authors: McCool D, Butler C, Evans J, Aase C Abstract A 43-year-old female scuba diver was retrieved and treated following a rapid ascent and presumed cerebral arterial gas embolism (CAGE). She subsequently developed respiratory distress and was found to have Takotsubo cardiomyopathy, with transient left ventricular dysfunction, elevated cardiac enzymes, and normal CT coronary angiography. We believe this to be the first report of CAGE associated with Takotsubo cardiomyopathy. PMID: 31523799 [PubMed - in process]
Conclusions: This study provides a strategy for understanding the mechanism of QLQX against CHF by combining pharmacokinetics study, network pharmacology, and experimental validation.