Arthritis diagnosis and early-life exposure to air pollution.

Arthritis diagnosis and early-life exposure to air pollution. Environ Pollut. 2019 Oct;253:1030-1037 Authors: Shepherd A, Mullins JT Abstract OBJECTIVES: Evaluate the relationship between arthritis diagnosis in those over 50 and exposure to extreme air pollution in utero or infancy (
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research

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Objective The aim of the study was to assess the time effect of intra-articular injection with triamcinolone hexacetonide in rheumatic patients. Design A prospective case-control study with patients submitted to one intra-articular injection with triamcinolone hexacetonide. Patients were followed monthly (12 mos) for pain and swelling. Results Two hundred sixty-two joints were assessed in 158 patients with mean ± SD age of 60 ± 13.7 yrs. Remission was observed at 3, 6, and 12 mos in 142 (54.19%), 111 (42.36%), and 105 (40.07%) joints, respectively. The mean ± SD time effect were 8 ± 4.0 ...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
This article is retrospective consecutive series of 110 valgus knees using CR implants with a minimum 2-year follow-up. Deformity correction was achieved using stepwise sequential soft tissue releases (iliotibial band, popliteus tendon, lateral collateral release through sliver femoral condylar osteotomy). Demographic data, range of movement, and degrees of deformity were collected. The Oxford Knee Score (OKS) was used as patients' reported outcome measure at final follow-up. One-hundred and four patients (110 knees) were included (87 females/17 males) with mean age of 68.7 years. Primary diagnosis was osteoarthritis in 85...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
MicroRNA‑34a‑3p inhibits proliferation of rheumatoid arthritis fibroblast‑like synoviocytes. Mol Med Rep. 2019 Jul 23;: Authors: Hou C, Wang D, Zhang L Abstract Rheumatoid arthritis (RA) is a chronic inflammatory joint disease characterized by synovial inflammation. Fibroblast‑like synoviocytes (FLS) serve a vital role in the initiation and perpetuation of the immune response in patients with RA. The present study aimed to investigate the potential role of microRNA (miR)‑34a‑3p in the pathogenesis of RA. FLS were collected from patients with RA and osteoarthritis (OA). The miR‑34a‑3p mi...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Our body is flexible due the joints. These joints connect two bones, provide support and help in the body parts movement. Joint pain is a feeling of discomfort, aches and soreness in any of our body ’s joint. There have been lots of cases of people having aches in their joints. These joint pains are due to injuries affecting the ligaments, bursae, or tendons surrounding the joint. Pain in the joints is also due to infection and inflammation and in an extremely rare case because of cancer. It becomes extremely painful when you try to move your body parts suffering this pain.There are different conditions which are res...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Publication date: Available online 9 September 2019Source: Life SciencesAuthor(s): Ramin Pourakbari, Meysam Khodadadi, Ali Aghebati-Maleki, Leili Aghebati-Maleki, Mehdi YousefiAbstractOsteoarthritis is a prevalent worldwide joint disease, which demonstrates a remarkable adverse effect on the patients' life modality. Medicinal agents, exclusively nonsteroidal anti-inflammatory drugs (NSAIDs), have been routinely applied in the clinic. But, their effects are restricted to pain control with insignificant effects on cartilage renovation, which would finally lead to cartilage destruction. In the field of regenerative medicine, ...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 6 September 2019Source: Best Practice &Research Clinical RheumatologyAuthor(s): Martijn A.H. Oude Voshaar, Mart A.F.J. van de LaarAbstractPatient-reported outcome measures are commonly used in the assessment of patients with musculoskeletal diseases. The present review provides an overview of historic and recent developments, including core set recommendations for assessing patient-reported outcomes in patients with fibromyalgia, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. The evidence supporting commonly used patient-reported outcomes measur...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
AbstractRheumatoid arthritis (RA) is a systemic, autoimmune disease that affects joints and extra-articular structures. In the last decade, the management of this chronic disease has dramatically changed with the introduction of several targeted mechanisms of action, such as tumor necrosis factor- α inhibition, T-cell costimulation inhibition, B-cell depletion, interleukin-6 blockade, and Janus kinase inhibition. Beyond its well-known hematopoietic role on the proliferation and differentiation of myeloid cells, granulocyte-monocyte colony-stimulating factor (GM-CSF) is a proinflammatory medi ator acting as a cytokine...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: The anti-CEP-1 is suitable for diagnosing of RA, but not superior to anti-CCP. PMID: 31471340 [PubMed - in process]
Source: Annals of Clinical and Laboratory Science - Category: Laboratory Medicine Authors: Tags: Ann Clin Lab Sci Source Type: research
Abstract Background and purpose - The Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) was analyzed to determine trends in use of primary total elbow arthroplasty (TEA), the types of prostheses used, primary diagnoses, reasons for and types of revision, and whether the primary diagnosis or prosthesis design influenced the revision rate. Patients and methods - During 2008-2018, 1,220 primary TEA procedures were reported of which 140 TEAs were revised. Kaplan-Meier estimates of survivorship were used to describe the time to first revision and hazard ratios (HR) from Cox proportional h...
Source: Acta Orthopaedica - Category: Orthopaedics Authors: Tags: Acta Orthop Source Type: research
In conclusion, IL-41 is expressed in PsA synovium and is present and inducible at the enthesis. Its functional effect in psoriatic inflammation remains to be fully elucidated. PMID: 31470086 [PubMed - as supplied by publisher]
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
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