Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431.

CONCLUSIONS.—: Myelodysplastic syndrome and acute myeloid leukemia in Down syndrome display features that allow discrimination from standard cases of disease. These distinctions are important for treatment decisions, and for understanding disease pathogenesis. We propose specific diagnostic criteria for Down syndrome-related subtypes of acute myeloid leukemia and myelodysplastic syndrome. PMID: 31429606 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31429606?dopt=Abstract

Source: Archives of Pathology and Laboratory Medicine - August 19, 2019 Category: Laboratory Medicine Authors: Mast KJ, Taub JW, Alonzo TA, Gamis AS, Mosse CA, Mathew P, Berman JN, Wang YC, Jones HM, Campana D, Coustan-Smith E, Raimondi SC, Hirsch B, Hitzler JK, Head DR Tags: Arch Pathol Lab Med Source Type: research