Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?

Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?
Trends Neurosci. 2019 Aug 14;:
Authors: Pa J, Andrews SJ, Swerdlow RH
Abstract
Multiple features distinguish the mitochondria of Alzheimer's disease (AD) patients from those of unaffected individuals. The causes and consequences of these differences are informed by the recent finding by Fleck et al. (J. Neurosci., 2019) that pentatricopeptide repeat-containing protein 1 (PTCD1) gene variants associate with AD. This suggests a proximal or initiating role for mitochondria in AD.
PMID: 31421943 [PubMed - as supplied by publisher]

Source: Trends in Neurosciences - August 13, 2019 Category: Neuroscience Authors: Pa J, Andrews SJ, Swerdlow RH Tags: Trends Neurosci Source Type: research