Changing epidemiology of KPC-producing Klebsiella pneumoniae in Argentina: Emergence of hypermucoviscous ST25 and high-risk clone ST307

ConclusionsDespite previous reports in Argentina, ST258 is no longer the absolute clone among KPC-Kp isolates. In the present study, dissemination of more virulent lineages such as the hypermucoviscous ST25 was detected. The emergence of the high-risk clone ST307 and occurrence of blaKPC-3 was noticed for the first time in this region.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research

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This study focused on the Escherichia coli possessing bla CTX-M genes in wastewater inflows. Crude 12 inflow water samples from wastewater treatment plant (WWTP) A and two samples each from other three WWTPs were collected in 2017 and 2018. A total of 73 E. coli isolates with 31 different STs harboring distinctive bla CTX-M gene repertoires were detected. In WWTP A influents, the bla CTX-M-14 (14 isolates) was dominant, followed by bla CTX-M-15 (12 isolates), bla CTX-M-27 (10 isolates). The chimeric bla CTX-M-64 and bla CTX-M-123 were each identified in one of E. coli isolates from the same WWTP A inflow port. The bla CTX-...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
Source: World Health Organization, Regional Office for South-East Asia. Published: 9/2019. This 35-page plan builds on and is aligned with the Global Strategic Plan to Strengthen Public Health Preparedness and Response; the World Health Organization's Global Action Plan on Antimicrobial Resistance; the Research and Development Blueprint for action to prevent epidemics; and the Pandemic Influenza Preparedness Framework. It is also guided by regional approaches, networks, and mechanisms for health emergency preparedness and response, such as the Asia Pacific Strategy for Emerging Diseases, a common strategic framework for t...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
Authors: Lai YC, Lu MC, Hsueh PR Abstract Introduction: Over the past few decades, Klebsiella pneumoniae has become a significant threat to public health and is now listed as an ESKAPE pathogen. Evolving with versatile capabilities, K. pneumoniae is a population composed of genetically and phenotypically diverse bacteria. However, epidemic K. pneumoniae are restricted to specific clonal lineages. The clonal group CG23 comprises hypervirulent K. pneumoniae displaying limited resistance to antimicrobials and is frequently associated with the community-acquired invasive syndrome. On the other hand, CG258 is another cl...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
Authors: Barkoff AM, He Q Abstract Although vaccination has been effective, Bordetella pertussis is increasingly causing epidemics, especially in industrialized countries using acellular vaccines (aPs). One factor behind the increased circulation is the molecular changes on the pathogen level. After pertussis vaccinations were introduced, changes in the fimbrial (Fim) serotype of the circulating strains was observed. When bacterial typing methods improved, further changes between the vaccine and circulating strains, especially among the common virulence genes including pertussis toxin (PT) and pertactin (PRN) were ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
CONCLUSIONS Our findings reinforce the idea that MSSA and MRSA strains should be carefully monitored, owing to their high pathogenic potential.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Conclusions/SignificanceExtensive phylogenetic diversity is evident amongst iNTS disease-associatedS. Enteritidis in Ghana. Antimicrobial resistance profiles differed by clade, highlighting the challenges of devising empirical sepsis guidelines. The detection of fluoroquinolone resistance in phyletically-related poultry and human isolates is of major concern and surveillance and control measures within the region ’s burgeoning poultry industry are required to protect a human population at high risk of iNTS disease.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract Clostridioides difficile is the major etiologic agent of nosocomial bacterial diarrhoea and pseudomembranous colitis. The pathogenesis of C. difficile infection (CDI)involves two cytotoxic enzymes (TcdA, TcdB) that cause colonic epithelial damage, fluid accumulation and enteritis. CDI has been demonstrated in a variety of animal species and some reports have recently raised the importance of wild animals as a reservoir of this pathogen and possible transmission to humans and domestic animals. The aim of this study was to characterize C. difficile isolates obtained from pet dogs in Rio de Janeiro, Brazil. ...
Source: Anaerobe - Category: Microbiology Authors: Tags: Anaerobe Source Type: research
ConclusionsDespite previous reports in Argentina, ST258 is no longer the absolute clone among KPC-Kp isolates. In the present study, the dissemination of more virulent lineages such as the hypermucoviscous ST25 was detected. Even more, it was noticed for the first time in our region the emergence of the high risk clone ST307 and also the occurrence of blaKPC-3.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 6 June 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Antonio J. Carcas, David Sevillano, Natalia González, Luis Alou, Rosa Gómez-Gil, Mario Muñoz, Lucia Llanos, Rafael J. Sanchez-Villanueva, Emilio Gonzalez-Parra, Maria-Jose Giménez, Lorenzo AguilarAbstractObjectivesBacterial viability and enrichment of resistance resulting from three different amikacin administration schedules with respect to haemodialysis (HD) were assessed against three OXA-48-producing Klebsiella pneumoniae (OXA48KP) strains isolated during an outbreak in Hospital Univers...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Limited information is available on antimicrobial susceptibility and clonal distribution of Staphylococcus aureus in the Caribbean region. The aims of this study were to determine the prevalence of antimicrobial resistance among clinical S. aureus isolates and to reveal the frequency and population structure of methicillin-resistant S. aureus (MRSA) in St Kitts and Nevis, a small island country in the West Indies. A total of 152 S. aureus were collected from consecutive samples submitted to the clinical microbiology laboratory of the main referral hospital from March 2017 to January 2018. Samples came from all units in the...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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