Significant association between 53BP1 expression and grade of intraepithelial neoplasia of esophagus: alteration during esophageal carcinogenesis

Conclusions53BP1-NF accumulation increases during cancer progression from LG-IN to HG-IN to CIS to SCC. Detection of 53BP1-NF by immunofluorescence, especially large foci, is a feasible method of estimating DNA instability and the malignant potential of esophageal intraepithelial neoplasia.
Source: Pathology Research and Practice - Category: Pathology Source Type: research