Naringenin and Atherosclerosis: a Review of Literatures.

Naringenin and Atherosclerosis: a Review of Literatures. Curr Pharm Biotechnol. 2014 Dec 1; Authors: Orhan IE, Nabavi SF, Daglia M, Tenore GC, Mansouri K, Nabavi SM Abstract Atherosclerosis is a multifactorial disease mainly caused by deposition of low-density lipoprotein cholesterol in macrophages of arterial walls. Atherosclerosis leads to heart attacks as well as stroke. Epidemiological studies showed that there is inverse correlation between fruit and vegetable consumption and risk of atherosclerosis. The promising effect of high vegetable and fruit containing diet on atherosclerosis is approved by several experimental studies on isolated phytochemicals such as flavonoids. Flavonoids are known to up-regulate endogenous antioxidant system, suppress oxidative and nitrosative stress, decrease macrophage oxidative stress through cellular oxygenase inhibition as well as interaction with several signal transduction pathways and from these ways, have therapeutic effects against atherosclerosis. Naringenin is a well known flavonoid belonging to the chemical class of flavanones. It is especially abundant in citrus fruits specially grapefruits. A plethora of evidences ascribes to naringenin anti-atherosclerotic effects. Naringenin abilities to decrease low-density lipoprotein (LDL) and triglycerides as well as inhibit glucose uptake; increase high-density lipoprotein (HDL); co-oxidation of NADH; suppress protein oxidation; protect against ...
Source: Current Pharmaceutical Biotechnology - Category: Biotechnology Authors: Tags: Curr Pharm Biotechnol Source Type: research