Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals

Conclusions In people of European ancestry, APOE genotype showed a positive dose-response association with LDL-C, C-IMT and ischaemic stroke. However, the association of APOE 2/2 genotype with ischaemic stroke requires further investigation. This cross-domain concordance supports a causal role of LDL-C on ischaemic stroke.

Source: International Journal of Epidemiology - April 8, 2013 Category: Epidemiology Authors: Khan, T. A., Shah, T., Prieto, D., Zhang, W., Price, J., Fowkes, G. R., Cooper, J., Talmud, P. J., Humphries, S. E., Sundstrom, J., Hubacek, J. A., Ebrahim, S., Lawlor, D. A., Ben-Shlomo, Y., Abdollahi, M. R., Slooter, A. J., Szolnoki, Z., Sandhu, M., War Tags: Genetic and Molecular Epidemiology Source Type: research