TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells.

In conclusion, we identify TRIM58 as a novel negative mediator of innate immune control and mucosal homeostasis via TLR2 signaling. Dysfunction of TRIM58 in myeloid cells may contribute to ulcerative colitis pathogenesis. PMID: 31383741 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31383741?dopt=Abstract

Source: Journal of Immunology - August 4, 2019 Category: Allergy & Immunology Authors: Eyking A, Ferber F, Köhler S, Reis H, Cario E Tags: J Immunol Source Type: research