Intratumoral Fusobacterium nucleatum levels predict therapeutic response to neoadjuvant chemotherapy in esophageal squamous cell carcinoma.

CONCLUSIONS: We conclude that high levels of intratumoral F. nucleatum have a prognostic significance for predicting poor RFS in ESCC patients. More importantly, our data indicates that higher F. nucleatum burden correlates with poor response to neoadjuvant chemotherapy, suggesting the possibility that an antibiotic intervention against this bacterium may significantly improve therapeutic response in ESCC patients. PMID: 31358543 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31358543?dopt=Abstract

Source: Clinical Cancer Research - July 28, 2019 Category: Cancer & Oncology Authors: Yamamura K, Izumi D, Kandimalla R, Sonohara F, Baba Y, Yoshida N, Kodera Y, Hideo B, Goel A Tags: Clin Cancer Res Source Type: research