Pro-apoptotic cell signaling in the prefrontal cortex contributes to depressive-/anxiogenic-like behavioral phenotype of mice subchronically exposed to dexamethasone

Publication date: Available online 30 July 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Suélen Osório Heck, Vanessa Angonesi Zborowski, Simone Pinton, Cristina Wayne NogueiraAbstractAnimal models have been used to investigate the depressive-/anxiogenic-like phenotype induced by synthetic glucocorticoids (GCs). The aim of the present study was to evaluate if apoptosis in the mouse prefrontal cortex (PFC) contributes to the depressive-/anxiogenic-like behavioral phenotype induced by dexamethasone (DEX) subchronic exposure. In the present study, adult male Swiss mice were exposed to DEX (2 mg/kg), or to saline solution (10 ml/kg), by the intraperitoneal route for 21 days. At the 22nd day, the mice performed anxiety- and depressive-like behavior tests. Subsequently, the samples of PFC were designated to the Western blot and Fluoro-Jade C staining analyses. The mice exposed to DEX exhibited a depressive-/anxiogenic-like phenotype, normal locomotor activity profile and a reduction in the weight of adrenal glands (% body weight). Reduced levels of GC receptors and an increase in the FJC-positive cells were found in the PFCs of mice subcronically exposed to DEX. The levels of pro-apoptotic protein cleaved caspase-3 and the ratios of PARP cleaved/total and Bax/Bcl-2 were increased in the PFCs of mice after subchronic exposure to DEX. These findings demonstrate that the pro-apoptotic cell signaling in the PFC contributed to the depressive-/anxiogen...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 14 December 2019Source: Journal of Contextual Behavioral ScienceAuthor(s): Tom Østergaard, Tobias Lundgren, Robert D. Zettle, Nils Inge Landrø, Vegard Øksendal HaalandAbstractThe Acceptance and Action Questionnaire (AAQ-II) aims to measure psychological flexibility (PF), described as the ability to act according to chosen values while consciously being in contact with present moment experiences that might function as obstacles. To date, the psychometric properties of a Norwegian translated version of the AAQ-II (NAAQ) have not been published, thus limiting the confide...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
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Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Medications Psychiatry psychiatric meds psychiatric prescriptions Source Type: blogs
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Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Anxiety Depression subscribers-only Source Type: blogs
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Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
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Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
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Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
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