Pro-apoptotic cell signaling in the prefrontal cortex contributes to depressive-/anxiogenic-like behavioral phenotype of mice subchronically exposed to dexamethasone

Publication date: Available online 30 July 2019Source: Journal of Chemical NeuroanatomyAuthor(s): Suélen Osório Heck, Vanessa Angonesi Zborowski, Simone Pinton, Cristina Wayne NogueiraAbstractAnimal models have been used to investigate the depressive-/anxiogenic-like phenotype induced by synthetic glucocorticoids (GCs). The aim of the present study was to evaluate if apoptosis in the mouse prefrontal cortex (PFC) contributes to the depressive-/anxiogenic-like behavioral phenotype induced by dexamethasone (DEX) subchronic exposure. In the present study, adult male Swiss mice were exposed to DEX (2 mg/kg), or to saline solution (10 ml/kg), by the intraperitoneal route for 21 days. At the 22nd day, the mice performed anxiety- and depressive-like behavior tests. Subsequently, the samples of PFC were designated to the Western blot and Fluoro-Jade C staining analyses. The mice exposed to DEX exhibited a depressive-/anxiogenic-like phenotype, normal locomotor activity profile and a reduction in the weight of adrenal glands (% body weight). Reduced levels of GC receptors and an increase in the FJC-positive cells were found in the PFCs of mice subcronically exposed to DEX. The levels of pro-apoptotic protein cleaved caspase-3 and the ratios of PARP cleaved/total and Bax/Bcl-2 were increased in the PFCs of mice after subchronic exposure to DEX. These findings demonstrate that the pro-apoptotic cell signaling in the PFC contributed to the depressive-/anxiogen...
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research

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Source: Psychology, Health and Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Background: The crisis in Syria has resulted in vast numbers of refugees seeking asylum in Syria's neighboring countries and Europe. Refugees are at considerable risk of developing common mental disorders, including depression, anxiety, and post-tra...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
In conclusion, this study identified a sex-biased effect of PTX on PFC function and gene expression, which provides a foundation for future studies to explore the precise mechanisms of PTX-induced behavioral deficits.
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 14 December 2019Source: Journal of Contextual Behavioral ScienceAuthor(s): Tom Østergaard, Tobias Lundgren, Robert D. Zettle, Nils Inge Landrø, Vegard Øksendal HaalandAbstractThe Acceptance and Action Questionnaire (AAQ-II) aims to measure psychological flexibility (PF), described as the ability to act according to chosen values while consciously being in contact with present moment experiences that might function as obstacles. To date, the psychometric properties of a Norwegian translated version of the AAQ-II (NAAQ) have not been published, thus limiting the confide...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
Psychiatric medications are an important part of treatment for many people with mental disorders, such as depression, bipolar disorder, ADHD, schizophrenia, anxiety, and others. They play an important role in helping to alleviate the most serious symptoms, allowing people to better focus on their lives and on other treatment types, such as psychotherapy. Psychiatric medications are an important part of many people’s treatment plans for obtaining the most effective treatment for a mental health concern or mental illness. It’s good to know what drugs are being prescribed most often for mental disorders in the U.S...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Medications Psychiatry psychiatric meds psychiatric prescriptions Source Type: blogs
Omega-3 is a type of fat, small amounts of which are essential for good health. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Anxiety Depression subscribers-only Source Type: blogs
A 21-year-old man sought treatment at an oral pathology center presenting with thick, brownish and peeling crusts along the upper and lower lips with a time-course evolution of 5 years. His main complaints were pruritus, burning sensation, and lack of aesthetics. Concomitantly with the onset of the lesions, the patient was diagnosed with anxiety disorder and depression. The diagnosis of exfoliative cheilitis was made based on the clinical characteristics and symptomatology reported by the patient.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Physical and chemical injuries of the oral mucosa can be caused by an accidental, iatrogenic, and factitious trauma. The present case describes chemical burn of oral mucosa caused by escitalopram oxalate. It belongs to a group of medicines used for relief of the symptoms of depression. A 27-year-old female patient presented with a 1-month history of an oral lesion with a burning sensation. Intraoral examination revealed a solitary white plaque on the ventral surface of the tongue. The patient reported medical treatment for anxiety and panic syndrome with a single daily dose of escitalopram (Lexapro) oral solution (20 mg/mL...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Many factors have been studied in order to identify the causes of oral lichen planus (OLP), such as use of drugs, autoimmune diseases, diabetes, and hepatitis C virus infection. Some researchers have been trying to find a connection between psychological states and OLP. The authors report a case of a 36-year-old female patient who went to the stomatology care service complaining of a "white ball on the tongue," which was causing her some discomfort over a year. During anamnesis, the patient reported taking lithium and bupropion (treating depression and anxiety, respectively).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
To evaluate psychological factors (anxiety, depression, and stress) and levels of salivary alpha-amylase in individuals with oral lichen planus.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
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