Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression

Wnt signaling plays a critical role in vascular calcification (VC). Wnt factors induce different physiological and pathological effects on cardiovascular functions. Wnt1, a ligand of Wnt/ β-catenin signaling, promotes pro-angiogenesis and reduces myocardial infarction. The role of Wnt1 on VC in chronic kidney disease (CKD) is not fully understood.

Source: Journal of Molecular and Cellular Cardiology - July 26, 2019 Category: Cytology Authors: Beidong Chen, Yang Zhao, Duanyang Han, Ban Zhao, Yonghui Mao, Zhong-Kai Cui, Yun-Chin Chu, Lu Feng, Sen Yin, Cun-Yu Wang, Xian Wang, Ming-Jiang Xu, Gexin Zhao Source Type: research