Predictive value of phenotypic signatures of bladder cancer response to cisplatin-based neoadjuvant chemotherapy.

CONCLUSIONS: The epithelial-mesenchymal transition phenotype and actin-cytoskeleton remodeling are associated with pathologic progression on NAC. Chemotherapy induced an mesenchymal-epithelial transition phenotype and decreased cofilin phosphorylation, providing new insights into therapeutic resistance mechanisms. Primary tumors with high apoptosis rates exhibited favorable response to NAC and lower mortality rates, indicating that these tumors may be sensitized to therapy. Further validation will establish these novel signatures as predictors of therapeutic response. PMID: 31326313 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31326313?dopt=Abstract

Source: Urologic Oncology - July 16, 2019 Category: Urology & Nephrology Authors: Hensley PJ, Kyprianou N, Purdom MS, He D, DiCarlo V, Wang C, James AC Tags: Urol Oncol Source Type: research