Different effect of a period of caloric restriction following treatment with a normal lipid or hyperlipidic diet in the experimental animal model: Focus on mitochondrial dynamics proteins in the liver

Publication date: August 2019Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 29, Issue 8Author(s): Vincenzo Migliaccio, Raffaella Sica, Marilena Lepretti, Rosaria Scudiero, Rosalba Putti, Lillà Lionetti
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research

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In this study, we show that PHA-4 regulates the expression of the ERAD component genes, the transient UPRER, as well as modulates UPRER at adulthood. These finding show that the transcription factor controls diverse aspects of the regulatory network that provides prolongevity benefits of DR, qualifying as the central regulator of this process. Link: https://doi.org/10.1073/pnas.1900055116
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Sepsis is a systemic inflammatory disease with infection, and autophagy has been shown to play an important role in sepsis. This review summarizes the main regulatory mechanisms of autophagy in sepsis and its latest research. Recent studies have shown that autophagy can regulate innate immune processes and acquired immune processes, and the regulation of autophagy in different immune cells is different. Mitochondrial autophagy can select damaged mitochondria and remove it to deal with oxidative stress damage. The process of mitochondrial autophagy is regulated by other factors. Non-coding RNA is also an important factor in...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that affects mostly the elderly population. At the moment, no effective treatments are available in the market, making the whole situation a compelling challenge for societies worldwide. Recently, novel mechanisms have been proposed to explain the etiology of this disease leading to the new concept that AD is a multifactor pathology. Among others, the function of mitochondria has been considered as one of the intracellular processes severely compromised in AD since the early stages and likely represents a common feature of many neurodegenera...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, mitochondrial dynamics participates in the control of hepatic glucose production.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research
Very few of the presently available interventions for aging are forms of rejuvenation, and of these most are debatable or have small, unreliable effects. Beyond senolytic drugs to clear some fraction of senescent cells from aging tissues, an approach that is producing sizable, reliable effects in animal studies and that will soon enough become a major part of healthcare for the old, other present treatments can only be argued to be forms of rejuvenation. Either they are not addressing root cause damage, or their effect sizes are so marginal as to make it unclear as to whether anything interesting is taking place. Consider ...
Source: Fight Aging! - Category: Research Authors: Tags: Activism, Advocacy and Education Source Type: blogs
Publication date: Available online 21 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Ju Gao, Luwen Wang, Tingxiang Yan, George Perry, Xinglong WangAbstractGenetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Importantly, TDP-43 proteinopathy, characterized by aberrant phosphorylation, ubiquitination, cleavage or nuclear depletion of TDP-43 in neurons and glial cells, is a common prominent pathological feature of various major neurodegenerative diseases including ALS, FTD, and Alzheimer's disease (AD). Although the pathomechan...
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
ConclusionCa2+ regulation influences the neurodegenerative process and there is possible role for perturbed calcium signaling in Mn neurotoxicity. Mechanisms implicated in Mn-induced neurodegeneration include oxidative stress, generation of free radicals, and apoptosis. These are influenced by mitochondrial integrity which can be dependent on intracellular Ca2+ homeostasis. Nevertheless, further elucidation of the direct effects of calcium signaling dysfunction and calcium-binding proteins activities in Mn neurotoxicity is required.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Publication date: November 2019Source: Journal of Functional Foods, Volume 62Author(s): Xuyun Liu, Ke Cao, Weiqiang Lv, Jing Liu, Jing Gao, Yan Wang, Chuan Qin, Jianshu Liu, Weijin Zang, Jiankang LiuAbstractIncreasing evidence demonstrates that hyperlipidemia plays a causal role in the development of cardiovascular diseases (CVDs) due to endothelial dysfunction. Houttuynia cordata aqueous extract (HAE), using as both medicine and food, whose effect and mechanism were investigated in endothelial dysfunction. In vivo, it profoundly attenuated hyperlipidemia-induced accumulation of serum metabolites, which in turn contributed...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
We report two siblings, from consanguineous parents, harbouring a previously uncharacterized homozygous variant in FBXL4 (c.1750 T > C; p.Cys584Arg). Both patients presented with encephalomyopathy, lactic acidosis and cardiac hypertrophy, which are reported features of FBXL4 impairment. Remarkably, dichloroacetate (DCA) administration to the younger sibling improved metabolic acidosis and reversed cardiac hypertrophy. Characterization of FBXL4 patient fibroblasts revealed severe bioenergetic defects, mtDNA depletion, fragmentation of mitochondrial networks, and abnormalities in mtDNA nucleoids. These phenotypes, o...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
The scientific community is saddened by the passing of Walter Neupert, an exceptional scientist and outstanding mentor, who contributed to shaping molecular cell biology over a career that spanned more than five decades. As a founder of the field of mitochondrial protein biogenesis, his research provided key mechanistic insights  into the fundamental process of cellular protein sorting and membrane translocation. Mitochondria have an important role in metabolism and cell regulation, and defects in their functions are a major cause of human diseases.
Source: Molecular Cell - Category: Cytology Authors: Tags: Obituary Source Type: research
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