Valerolactones and healthy Ageing: Linking Dietary factors, nutrient biomarkers, metabolic status and inflammation with cognition in older adults – The VALID Project

Introduction: Several studies identified nuts, berries, cocoa, red wine and tea as preventive toward cognitive decline. These foods are rich in flavan-3-ols (F3O), among which (epi)catechin and procyanidins. However, these compounds are poorly absorbed in the upper gastro-intestinal tract and are metabolized by colonic bacteria to phenyl- γ-valerolactones (PVL), which showed biological activities and might represent better dietary exposure biomarkers compared to (epi)catechin conjugates, as they reach higher plasma Cmax and tmax.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - July 20, 2019 Category: Nutrition Authors: Donato Angelino, Benjamin Paramenter, Katie Moore, Chris Gill, Pedro Mena, Alice Rosi, Eamon Laird, Adrian Moore, Michaela Black, Mary Ward, Sean Strain, Anne Marie Molloy, Daniele Del Rio, Helene McNulty Source Type: research