Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures.

CONCLUSIONS: Our significant results indicate that MDD case-control differences in RACC thickness vary as a function of SCZ PRS. Although this was not the case for most other brain measures assessed, our specific findings still provide some further evidence that MDD in the presence of high genetic risk for SCZ is subtly neurobiologically distinct from MDD in general.
PMID: 31317844 [PubMed - as supplied by publisher]

Source: Psychological Medicine - July 17, 2019 Category: Psychiatry Authors: Harris MA, Shen X, Cox SR, Gibson J, Adams MJ, Clarke TK, Deary IJ, Lawrie SM, McIntosh AM, Whalley HC Tags: Psychol Med Source Type: research