Lymphatic clearance is the main drainage route of lamotrigine ‐loaded micelles following delivery to the brain

ConclusionsThese results suggested that lamotrigine micelles were primarily cleared from the brain by lymphatics rather than blood clearance. Also, the nanoparticle induced the increase in IL ‐6 level after entering the brain suggested that nanoparticles might induce the inflammation promoted by IL‐6 in the brain, accelerating the clearance of drug particles in the brain and drainage through lymphatics.

Source: Journal of Pharmacy and Pharmacology - July 16, 2019 Category: Drugs & Pharmacology Authors: Jiaqi Yan, Jialin Ren, Yu Zhu, Yanzhen Lin, Gang Chen, Dongzhi Hou, Zhufen Lv, Jiaxin Zhou, Yanzhong Chen, Fan Yang Tags: Research Paper Source Type: research