TGF ‐β‐mediated regulation of plasminogen activators is human telomerase reverse transcriptase dependent in cancer cells

In this study, we show a positive association between hTERT and uPA. We also demonstrate that hTERT enhances uPA expr ession concomitant with EMT. Knocking down of hTERT reduces uPA expression as well as reverses EMT in cancer cells. We have also found that uPA is a transforming growth factor beta (TGF‐β)‐induced protein. Our observations establish that TGF‐β‐induced uPA expression is hTERT dependent.
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research