Anti-inflammatory effect of statin is continuously working throughout use: a prospective three time point 18 F-FDG PET/CT imaging study

AbstractNo data exist whether statins have robust anti-inflammatory effects of atherosclerotic plaques primarily during the early treatment period or continuously throughout use. This prospective three time point18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) study of the carotid artery assessed anti-inflammatory effects of statin during the early treatment period (initiation to 3  months) and late treatment period (3 months to 1 year) and their correlation with lipid and inflammatory profile changes during a year of therapy. Nine statin-naïve stable angina patients with inflammatory carotid plaques received 20 mg/day atorvastatin after undergoing initial18F-FDG PET/CT scanning of carotid arteries and ascending thoracic aorta, and then completed serial18F-FDG PET/CT imaging at 3 and 12  months whose data were analyzed. The primary outcome was the inter-scan percent change in target-to-background ratio (ΔTBR) within the index vessel. At 3 months of atorvastatin treatment, mean serum low-density lipoprotein cholesterol (LDL-C) level decreased by 36.4% to  40 mg/dL (p = 0.041), with both maintained with no further reduction up to 1 year (p = 0.516 and 0.715, respectively) while mean serum high sensitivity C-reactive protein level only numerically decreased (p = 0.093). The index vessel ΔTBR showed continuous plaque inflammation reduc ...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research

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In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study provides characterization of a lipid-rich necrotic core, a dangerous type of coronary plaque made up of dead cells and cell debris that is prone to rupture. Ruptured plaque can lead to a heart attack or stroke. The analysis involved 209 middle-aged patients (ages 37-62) with psoriasis who participated in the Psoriasis Atherosclerosis Cardiometabolic Initiative at the National Institutes of Health, an ongoing observational study. Of these participants, 124 received biologic therapy, and 85 were in the control group, treated only with topical creams and light therapy. To measure the effects of biologic ther...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusions: In a cohort of NAFLD-HCC patients, statin use was protective against HCC, while hypertension conferred an increased risk. Visceral adiposity at baseline was not a risk factor, but was higher in male patients before HCC development, declining in the majority by HCC diagnosis.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: LIVER, PANCREAS & BILIARY TRACT: Original Articles Source Type: research
This study assesses the current practices of physicians in Lebanon routinely involved in ischemic stroke (IS) management. We conducted a prospective observational study of patients hospitalized at 8 different Lebanese hospitals in the period August 1, 2015 to July 31, 2016, with a diagnosis of acute stroke. Baseline characteristics and data on diagnostic studies, as well as treatments received during hospitalization and at discharge, were collected and analyzed. Two hundred and three strokes/transient ischemic attacks (TIAs) were recorded but only 173 patients (85%) with ischemic events were included in the study. The pati...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
If you have a CT heart scan score (also called coronary calcium score), what effect do statin cholesterol drugs have on stopping or slowing the increase in score? (Increasing scores pose increasing risk for heart attack and other cardiac events.) NONE. If you do nothing at all, the score increases by 25% per year, on average. If you take a statin drug, aspirin, and follow a low-fat diet, what my colleagues call “optimal medical therapy,” the score increases . . . 25% per year—no difference. Yet this is the “solution” that conventional doctors push on their patients, a “treatment” t...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open cholesterol coronary calcium ct scan do statin drugs reduce heart scan scores reduce coronary calcium reverse coronary calcium reverse heart disease undoctored wheat belly Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Researchers are using artificial intelligence to measure a common marker of heart disease via lung cancer screenings. The research was presented at the annual meeting of the Radiological Society of North America (RSNA). Low-dose chest CT is approved for lung cancer screening in high-risk people, such as long-time smokers. While these CT scans are intended to diagnose lung cancer, coronary artery calcium, a measure of plaque in the arteries, is also visible on CT. The coronary artery calcium score derived from CT is a well-established measure that helps doctors decide who should get cholesterol-lowering preventive medicatio...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health IVD Source Type: news
Publication date: Available online 30 October 2019Source: Journal of Vascular and Interventional RadiologyAuthor(s): Timothy C. Huber, Nicole Keefe, James Patrie, Margaret C. Tracci, Daniel Sheeran, John F. Angle, Luke R. WilkinsAbstractPurposeTo evaluate psoas muscle area (PMA) as a predictor of all-cause mortality after endovascular aneurysm repair (EVAR) and compare it with other predictor variables.Material and MethodsRetrospective review of 407 patients who underwent EVAR over a 7-year period was performed. Demographics, comorbidity variables, and outcomes were collected. Preprocedure computed tomography scans were us...
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
By measuring the percentage of pulmonary fibrosis on CT exams in lung cancer...Read more on AuntMinnie.comRelated Reading: Risk models boost efficiency of CT lung cancer screening AI predicts lung cancer survival from CT scan data AI reliably characterizes pulmonary nodules on CT Lung abnormalities at CT linked to in-hospital death CT shows link between statins and lung abnormalities in smokers
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
We describe 2 cases of acute carpal tunnel syndrome due to thrombosed persistent median artery, including a case of thromboangiitis obliterans. These thrombosis might also be due to traumatic causes. No guidelines are currently available to help physicians for the management of carpal tunnel syndrome from thrombosed persistent median artery. Antiplatelet therapy, statin, anticoagulant might be helpful, and surgery has sometimes be reported as effective. PMID: 31040049 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
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