HDAC3 positively regulates HE4 expression to promote ovarian carcinoma progression.

CONCLUSION: HDAC3 expression is higher in ovarian cancer and promotes ovarian cancer cell proliferation, invasion and migration. HDAC3 and HE4 binding activates the PI3K/AKT signaling pathway, enhances ovarian cancer and promotes ovarian cancer cell proliferation, invasion and migration. PMID: 31302139 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31302139?dopt=Abstract

Source: Archives of Biochemistry and Biophysics - July 10, 2019 Category: Biochemistry Authors: Lou T, Zhuang H, Liu C, Zhang Z Tags: Arch Biochem Biophys Source Type: research