Reducing Healthcare Costs; Surgery at a Selected Hospital and Pharma Tourism

Individuals and self-insured companies have adopted various strategies to reduce the rising cost of healthcare for themselves and their employees. A recent article discussed howWalmart was flying employees who were candidates for particular surgical procedures to selected, distant hospitals for evaluation (see:Walmart Flies Employees to Top Hospitals for Surgeries in a Bid to Cut Healthcare Costs). Below is an excerpt from it:Walmart ’s answer [to rising healthcare costs] is its six-year-oldCenters of Excellence (COE) program. In partnership with third-party administrator Health Design Plus (HDP), Walmart directly contracts with the following leading medical centers for procedures, such as hip or knee replacements, heart or back surgery, or cancer treatments: Cleveland Clinic in Ohio; Geisinger Medical Center in Pennsylvania; Mayo Clinic in Arizona, Florida, and Minnesota; and Virginia Mason Medical Center in Seattle. Patients incur no out-of-pocket costs for travel to a COE facility and most plan procedures and consultations are fully covered. Until 2018, the COE program was optional for Walmart employees. Now, employees may be on the hook for the entire cost if they opt to have a covered procedure performed locally....General Electric, Lowe ’s, McKesson, and Boeing also are directly contracting with high-quality healthcare providers to control costs and improve outcomes.In Utah, medical tourism of another kind is bringing down employer healthcare costs....[A] st...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: Cost of Healthcare Healthcare Innovations Healthcare Insurance Medical Consumerism Pharmaceutical Industry Public Health Quality of Care Source Type: blogs

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Abstract Rheumatoid arthritis (RA) is a chronic inflammation mediated by autoimmune responses. MEG3, a kind of long noncoding RNA (lncRNA), participates in cell proliferation in cancer tissues. However, the correlation between MEG3 and RA is yet unclear. Therefore, to clarify how MEG3 works in RA, we performed a series of experiments using RA samples. We found that MEG3 was downregulated in the fibroblast-like synoviocytes of RA patients (RA-FLS), in comparison with healthy subjects. MEG3 was also down-regulated evidently in lipopolysaccharide (LPS)-treated chondrocyte. As part of our experiments, MEG3 was overexp...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research
Abstract The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially identified as an inducer of follicle-stimulating hormone secretion. Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and...
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research
AbstractThe Innovation and Value Initiative started the Open-Source Value Project with the aim to improve the credibility and relevance of model-based value assessment in the context of the US healthcare environment. As a core activity of the Open-Source Value Project, the Innovation and Value Initiative develops and provides access to flexible open-source economic models that are developed iteratively based on public feedback and input. In this article, we describe our experience to date with the development of two currently released, Open-Source Value Project models, one in rheumatoid arthritis and one in epidermal growt...
Source: PharmacoEconomics - Category: Health Management Source Type: research
AbstractMolecules secreted by cells into the internal environment during aging, including those secreted in exosomes, have long been a matter of concern. Those cells that absorb exosomes, also known as recipient cells, exhibit certain phenotypic changes because of the regulatory role of functional molecules (including proteins and nucleic acids) released in exosomes. Involvement of noncoding RNAs (ncRNAs) in the regulation of aging has received increasing attention, and long ncRNAs (lncRNAs) have become one of the research hotspots in recent years. LncRNAs carried by exosomes play a role in intercellular communication betw...
Source: IUBMB Life - Category: Research Authors: Tags: CRITICAL REVIEW Source Type: research
ConclusionThe occurrence of a flare/IRAE is frequent but mostly manageable without ICI discontinuation in patients with PAD. Immunosuppressive therapy at baseline was associated with poorer outcomes.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Breastfeeding beyond infancy Breastfeeding beyond infancy benefits mother and baby. For children, this may include balanced nutrition, boosted immunity and improved health. For mothers, breastfeeding longer may include improved health and reduced risk of illnesses such as breast and ovarian cancer, rheumatoid arthritis, heart disease, and diabetes. The American Academy of Pediatrics recommends exclusive breastfeeding [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
CONCLUSION: Analysis of long-term data from this prospective real-world registry demonstrated a safety profile consistent with previous studies in patients with RA. This analysis did not identify any new safety signals associated with adalimumab treatment and provides valuable guidance for physicians prescribing adalimumab for extended periods of time. PMID: 31371657 [PubMed - as supplied by publisher]
Source: J Rheumatol - Category: Rheumatology Authors: Tags: J Rheumatol Source Type: research
ConclusionsTherefore, GAS5 overexpression may improve RA by downregulating IL-18 and inducing the apoptosis of fibroblast-like synoviocytes.Key points•The present study mainly showed that overexpression of GAS5 may assist the treatment of RA.•The mechanism of GAS5 for the treatment of RA involves the downregulating inflammatory IL-18 and mediating the apoptosis of fibroblast-like synoviocytes.•GAS5 and IL-8 were correlated in RA patients but not in healthy controls.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Abstract Osteoclastogenesis-related bone diseases including osteoporosis, rheumatoid arthritis, Paget's disease and periodontitis are worldwide occurred and cause severe health problems including bone fracture and bone cancer. However, A few studies have shown that Daemonorops draco (Willd.) Blume may decrease bone destruction and relieve bone cancer pain. In this research, we isolated and purified four known and two novel compounds from D. draco and investigated their anti-osteoclastogenesis activity using RAW264.7 cells. Among them, com.1 exhibited the most effective inhibitory activity on osteoclastogenesis wit...
Source: Fitoterapia - Category: Biochemistry Authors: Tags: Fitoterapia Source Type: research
Publication date: Available online 26 July 2019Source: Pharmacology &TherapeuticsAuthor(s): In Jun Yeo, Chong-Kil Lee, Sang-Bae Han, Jaesuk Yun, Jin Tae HongAbstractChitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is strongly increased by various inflammatory and immunological conditions, including rheumatoid arthritis, multiple sclerosis, Alzheimer’s disease, and several cancers. However, its physiological and pathophysiological roles in the development of cancer and neurodegenerative and inflammato...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
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