Human respiratory syncytial virus infection in the pre-clinical calf model.

In this study, we aim to describe viral kinetics and (clinical) disease characteristics in calves inoculated with hRSV. Our results show that hRSV infects the upper and, to a lesser extent, the lower respiratory tract of calves. Infection causes upper airway clinical disease symptoms and neutrophilic infiltration of the lower airways. We conclude that a hRSV model in calves may aid future research involving distinct scientific questions related to hRSV disease in children.
PMID: 31300116 [PubMed - in process]

Source: Comparative immunology, microbiology and infectious diseases. - July 15, 2019 Category: Allergy & Immunology Authors: Cortjens B, de Jong R, Bonsing JG, van Woensel JBM, Bem RA, Antonis AFG Tags: Comp Immunol Microbiol Infect Dis Source Type: research