Response to combined ipilimumab and nivolumab after development of a nephrotic syndrome related to PD-1 monotherapy

ConclusionThis case illustrates that a fulminant response to combined checkpoint inhibition is possible after progression after anti-PD-1 monotherapy and a severe irAE.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research

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In this study, we determined the impacts of growth pattern to the end of the mating period and sire genetics on the reproductive performance of Merino ewe lambs. Five hundred ewe lambs with full pedigree records were managed under commercial conditions from weaning and weighed 43.5 kg at the start of the mating period with an average age of 224 days. The ewe lambs were offered a moderate or high feed allowance to achieve target growth rates of 100 or 200 g/day during a 46-day mating period. They were then recombined and scanned for pregnancy status 60 days after the mating period. At the individual animal lev...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Source: Journal of Biopharmaceutical Statistics - Category: Statistics Authors: Source Type: research
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
Publication date: Available online 16 August 2019Source: Physiology &BehaviorAuthor(s): Rodolfo Ungerfeld, Aline Freitas-de-MeloAbstractHigh progesterone concentrations reduce the stress responses in several mammals. Therefore, it may be expected that pregnant ewes have lower responses to stressors than anoestrous ewes. Our aims were to compare the stress response and the behavioural changes of pregnant and non-pregnant ewes sheared during winter. Two trials were with 20 were pregnant (group PR) and 17 non-pregnant ewes (group NP). In the first trial blood samples were collected immediately before and during the first ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Ameni Sakka, Aycha Jellali, Besma Hamdi, Mohammed S.M. Abdelbaky, Houcine Naïli, Santiago García-Granda, Ridha ZouariAbstractA novel inorganic-organic hybrid material of bis (5,7-dichloro-8-hydroxyquinolium) tetrachlorozincate (II) dihydrate was crystallized and characterized by IR, Raman, 13C NMR spectroscopy, scanning electron microscopy (SEM) and thermal analyses (TG/DTG/SDTA). The solid-state structures were determined by single crystal X-ray diffraction. The compound was found to crystallizes in the non-centrosy...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
CONCLUSIONS The effect of PL on the SDF-1-CXCR4/CXCR7 axis has become an attractive target for inhibiting angiogenesis in hepatoma cells. Our results provide more evidence for the clinical application of PL as part of traditional Chinese medicine in modern cancer treatment. PMID: 31415486 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In conclusion, quantitative evaluation of the performance of the method proved its improved accuracy compared to other current state-of-art techniques, and it showed robust performance even with noise and a narrow overlapping region between adjacent fields.
Source: Micron - Category: Biology Source Type: research
In conclusion, this study recognized linc00460 as a new oncogenic lncRNA in OS and suggests that the linc00460/miR-1224-5p/FADS1 axis might be a potential therapeutic target for OS.
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 August 2019Source: Journal of Theoretical BiologyAuthor(s): M. Chowkwale, G.J. Mahler, P. Huang, B.T. MurrayAbstractEndothelial to mesenchymal transformation (EndMT) is a process in which endothelial cells gain a mesenchymal-like phenotype in response to mechanobiological signals that results in the remodeling or repair of underlying tissue. While initially associated with embryonic development, this process has since been shown to occur in adult tissue remodeling including wound healing, fibrosis, and cancer. In an attempt to understand the role of EndMT in cancer progression and meta...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: 15 November 2019Source: Carbohydrate Polymers, Volume 224Author(s): Asma Sharkawy, Maria Filomena Barreiro, Alírio Egídio RodriguesAbstractRecently, there has been a renewed interest in Pickering emulsions owing to their surfactant-free nature, and the use of natural-based particles as stabilizers became a priority due to the applications they can enable. In this work, chitosan/gum Arabic (CH/GA) nanoparticles were synthesized and tested as novel stabilizers. Among the tested CH/GA weight ratios, the particles prepared using 1:1 ratio exhibited near-neutral wettability, an average size of 10...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
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