Al 18 F-labeled alpha-melanocyte-stimulating hormone ( α-MSH) peptide derivative for the early detection of melanoma

ConclusionsWe successfully prepared Al18F-NOTA-GGNle-CycMSHhex in a simple and efficient manner. Al18F-NOTA-GGNle-CycMSHhex showed high tumor accumulation and clearly visualized very small tumors in melanoma-bearing mice. These findings suggest that Al18F-NOTA-GGNle-CycMSHhex will be a promising PET tracer for melanoma imaging at an earlier stage.

http://link.springer.com/10.1007/s12149-019-01383-4

Source: Annals of Nuclear Medicine - July 4, 2019 Category: Nuclear Medicine Source Type: research