[Research Articles] An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

This study supports the existence of an IgG-neutrophil pathway in human NMBA-induced anaphylaxis, which may aggravate anaphylaxis in combination with the IgE pathway or underlie anaphylaxis in the absence of specific IgE. These results reconcile clinical and experimental data on the role of antibody classes in anaphylaxis and could inform diagnostic approaches to NMBA-induced acute hypersensitivity reactions.

Source: Science Translational Medicine - July 9, 2019 Category: Biomedical Science Authors: Jönsson, F., de Chaisemartin, L., Granger, V., Gouel-Cheron, A., Gillis, C. M., Zhu, Q., Dib, F., Nicaise-Roland, P., Ganneau, C., Hurtado-Nedelec, M., Paugam-Burtz, C., Necib, S., Keita-Meyer, H., Le Dorze, M., Cholley, B., Langeron, O., Jacob, L Tags: Research Articles Source Type: research